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壳聚糖衍生物在抗肿瘤方面的研究进展
引用本文:王晓霁,杨靖亚,刘建文.壳聚糖衍生物在抗肿瘤方面的研究进展[J].中国临床药理学与治疗学,2008,13(8):952-956.
作者姓名:王晓霁  杨靖亚  刘建文
作者单位:1. 上海海洋大学食品学院,上海,200090
2. 华东理工大学药学院,上海,200237
基金项目:上海市重点学科建设项目
摘    要:随着科学理论和实践研究的进展,壳聚糖衍生物在抗肿瘤方面应用有所突破。壳聚糖衍生物因其稳定性、生物相容性、生物可降解性、低毒性、体内长期保留性等优点,显示出了良好的研究前景。本文综述了壳聚糖衍生物抗肿瘤性质、作为药物载体应用以及对物理治疗辅助作用。这些资料都说明了壳聚糖衍生物在抑制肿瘤生长和延长存活期方面起到了积极作用。

关 键 词:壳聚糖衍生物  抗肿瘤  载体

Research progress of chitosan derivatives in antitumor studies
WANG Xiao-ji,YANG Jing-ya,LIU Jian-wen.Research progress of chitosan derivatives in antitumor studies[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(8):952-956.
Authors:WANG Xiao-ji  YANG Jing-ya  LIU Jian-wen
Institution:WANG Xiao-ji, YANG Jing-ya , LIU Jian-wen (1.College of Food Science and Technology, Shanghai Ocean University, Shanghai 200090, China ; 2. College of Pharmaceutical Sciences, East China University of Science and Technology, Shanghai 200237, China )
Abstract:Application of chitosan derivatives in antitumor studies had gained great progress with the development of theory and practiee, whieh exhibited good prospect for its favourable properties, such as stability, biocompatibility, biodegradability, low toxieity and long-term retention in the body. Antitumor properties of chitosan derivatives, application of chitosan derivatives as drug earrier and auxiliary function of physieal thempy were concluded in this review. The data showed that chitosan derivatives played an active role in suppression of tumour growth and prolongation of survival period.
Keywords:chitosan derivatives  antitumor  carrier
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