|
|||||
|
|
| 男性慢性盆腔疼痛综合征患者前列腺液中肿瘤坏死因子受体浓度测定 | |
| 引用本文： | 陈荣生,罗冬娇,陈立,童夏生,陈豪,王恩智.男性慢性盆腔疼痛综合征患者前列腺液中肿瘤坏死因子受体浓度测定[J].中国临床药理学与治疗学,2009,14(11):1304-1307. |
| 作者姓名： | 陈荣生 罗冬娇 陈立 童夏生 陈豪 王恩智 |
| 作者单位： | 1. 台州市中西医结合医院泌尿外科,附属浙江中医药大学第一临床医学,台州,317523,浙江 2. 台州市中西医结合医院泌尿外科,杭州师范大学钱江学院医学系,杭州,310012,浙江 3. 台州市中西医结合医院儿科,附属浙江中医药大学第一临床医学,台州,317523,浙江 4. 台州市中西医结合医院泌尿外科,台州市中西医结合医院病理科,台州,317523,浙江 5. 台州市中西医结合医院泌尿外科,台州市中西医结合医院检验科,台州,317523,浙江 |
| 摘 要： | 目的：检测肿瘤坏死因子受体（sTNF-R1和sTNF-R2）在男性慢性盆腔疼痛综合征（CPPS）患者前列腺液中的表达水平，探讨sTNF-R1和sTNF-R2在CPPS炎症过程中的可能作用机制。方法：cPPS患者均来自2008年3月-2009年1月，其中ⅢA级24例、ⅢB级20例，并与15例健康人作对照。直肠按摩取出前列腺液，EusA法检测前列腺液sTNF-R1和sTNF-R2的蛋白浓度。结果：CPPSⅢA组前列腺液sTNF-R1和sTNF．1t2的蛋白浓度显著高于ⅢB组（46±6粥41±6），P〈0．05；（13．0±4．8US7．9±4．1）ng／mL，P〈0．01]且ⅢB组前列腺液srINF-R1和sTNF．R2的蛋白浓度显著高于对照组分别为（25±8）、（2．5±1．9）ng／mL，均P〈0．01]。结论：男性CPPS患者前列腺液中sTNF-R1和sTNF-R2的蛋白浓度增加，两者可能共同参与了CPPS的炎症过程。 |
| 关 键 词： | 慢性盆腔疼痛综合征 肿瘤坏死因子 受体 酶联免疫吸附试验 |
Concentrations of tumor necrosis factor receptors at prostatic secretion in male patients with chronic pelvic pain syndrome |
|
| CHEN Rong-sheng,LUO Dong-jiao,CHEN Li,TONG Xia-sheng,CHEN Hao,WANG En-zhi.Concentrations of tumor necrosis factor receptors at prostatic secretion in male patients with chronic pelvic pain syndrome[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2009,14(11):1304-1307. | |
| Authors: | CHEN Rong-sheng LUO Dong-jiao CHEN Li TONG Xia-sheng CHEN Hao WANG En-zhi |
| Institution: | 1Department of Urinary Surgery, Taizhou Integrated Western and Traditional Chinese Medicine Hospital, Affiliated to the First Clinical Medicine of Zhejiang Chinese Medical University, Taizhou 317523, Zhejiang, China; 21)- ePartment of Medical Science, Qianjiartg College, Hangzhou Normal University, Hanzhou 310012, Zhejiang , Chi- na ; 3Department of Pediatrics, 4Department of Pathology, 5Department of Clinical Laboratory, Taizhou Integrated Western and Traditional Chinese Medicine Hospital, Affiliated to the First Clinical Medicine of Zhejiang Chinese Medical University, Taizhou 317523, Zhejiang, China) |
| Abstract: | AIM:To detect the concentrations of solube tumor necrosis factor receptors(sTNF-R1 and sTNF-R2)at prostatic secretion in male patients with chronic pelvic pain syndrome(CPPS).And to investigate the potential roles of sTNF-R1 and sTNF-R2 in the development of CPPS inflammation.METHODS:All the patients were obtained during March 2008 to January 2009 including 24 cases of CPPS HI A and 20 cases of CPPS Ⅲ B,and were compared to 24 cases of volunteers.Expressed prostatic secretion were obtained by rectum massage methods.Concentrations of sTNF-R1 and sTNF-R2 were measured by enzyme linked immunosorbent assay methods.RESULTS:The concentrations of sTNF-R1 and sTNF-R2 proteins were significantly higher from CPPS Ⅲ A group than those from CPPS Ⅲ B group(46 ± 6 vs 41 ± 6),P＜0.05,(13.0±4.8 vs 7.9±4.1)ng/mL,P＜0.01],and they were dramaticly higher from CPPS Ⅲ B group than those from compared group(25 ± 8),(2.5 ± 1.9)ng/mL,all P＜0.0l].CONCLUSION:Concentrations of sTNF-R1 and sTNF-R2 proteins are increased in male patients with CPPS.Both of them may be associated with the development of CPPS inflammation. |
| Keywords: | chronic pelvic pain syndrome tumor necrosis factor receptor enzyme linked immunosorbent assay |
| 本文献已被 维普 万方数据 等数据库收录！ | |