纳洛酮治疗慢性阻塞性肺疾病并肺性脑病46例临床观察

目的探讨纳洛酮治疗慢阻肺疾病并肺性脑病的临床效果。方法将46例慢阻肺并肺性脑病患者随机分为治疗组和对照组,每组23例。2组均给予常规治疗,治疗组在此基础上加以纳洛酮应用,首剂0.8 mg加入生理盐水20 ml静脉推注,续以纳洛酮0.8 mg加生理盐水100 ml静滴,bid,连用3～5 d。观察2组患者的临床疗效,治疗前后的临床症状、体征、肺功能、血气分析结果、疗程和不良反应发生情况。结果治疗组有效率明显高于对照组;治疗后,2组患者的血气分析结果临床症状均较治疗前改善,而治疗组治疗后动脉血气分析结果明显优于对照组,并且患者临床缓解所需时间少于对照组,2组均无明显不良反应发生。结论纳洛酮治疗慢阻肺并肺性脑病安全有效。

Clinical effect of naloxone in the treatment of COPD combined with Pulmonary encephalopathy:an observation of 46 cases

Objective To study the clinical effect of naloxone in the treatment of chronic obstructive pulmonary disease（COPD） combined with pulmonary encephalopathy（PE）.Methods 46 cases of patients with COPD and PE were randomly divided into a treatment group and a control group,23 patients in each group.Both groups were given conventional treatment.Naloxone was added to the treatment group,with first agent 0.8 mg intravenously injected with physiological saline 20 ml,continued by naloxone 0.8 mg with intravenous drip of physiological saline 100 ml,bid,keeping 3~5 days.The clinical effect of the two groups of patients was observed before and after the treatment in terms of clinical symptoms,physical signs,pulmonary function,results of blood gas analysis,course of treatment and adverse reactions.Results The treatment group displayed obviously higher therapeutic effect than the control group.After the treatment,the two groups both improved in blood gas analysis results and clinical symptoms.But the result of arterial blood gas analysis of the treatment group was obviously superior to that of the control group,and less time was needed for clinical remission.No obvious adverse reaction occurred in either group.Conclusion The treatment of COPD and PE with naloxone is safe and effective.