Anti-interferon antibody increases rhinovirus isolation rates from nasal wash specimens containing interferon-alpha 2 |
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Authors: | F G Hayden J M Gwaltney |
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Institution: | 1. Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, U.S.A.;2. Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, U.S.A. |
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Abstract: | Isolation of rhinoviruses from nasal secretions may be delayed or prevented by exogenously applied interferon which is carried over into nasal wash specimens. In studies of interferon-alpha 2 treated volunteers with experimental rhinovirus infection, we determined that incorporation of antiinterferon antibody into collection broth significantly increased isolation rates (84% increase) and the proportion of monolayers positive for CPE (155% increase), as compared to plain collection broth. |
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Keywords: | rhinovirus isolation anti-interferon antibody |
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