呼出气分析在胃癌筛查和诊断中的研究进展

近年来,胃癌的发病率和病死率都呈现上升趋势,已成为威胁健康的重大疾病之一,其诊断方法一直备受关注。由于呼出气诊断癌症具有无创、依从性高、易于操作、临床应用前景广等优点,目前已经成为癌症诊断的热门研究方向。现将胃癌呼出气诊断的相关研究进展进行归纳总结。介绍目前应用于胃癌呼出气研究的分析技术,并主要阐述呼出气挥发性有机化合物、呼出气冷凝液中与胃癌相关的肿瘤标志物,以期为呼出气早期筛查和诊断胃癌提供更多的参考依据。

Research progress of exhaled breath analysis in screening and diagnosis of gastric cancer

In recent years,the incidence and mortality of gastric cancer are on the rise,which has became a major disease threatening health,and its diagnostic methods have attracted much attention.Exhaled breath test for cancer has the advantages of non-invasion,high compliance,simple operation and promising prospects of clinical application,thus becoming the popular research area of cancer diagnosis.In this paper,the progress of gastric cancer diagnosis on exhaled breath is summarized.The analysis technique of exhaled breath test in gastric cancer and the biomarkers in the exhaled breath volatile organic compounds (VOCs),exhaled breath condensate (EBC) associated with gastric cancer are introduced.It is expected to provide more reference for early screening and diagnosis of gastric cancer with exhaled breath.