黄州地区胃癌与慢性胃炎相关影响因素配对病例对照研究

目的：分析黄州地区胃癌与慢性胃炎相关影响因素，为研究胃癌的发病诱因和防治措施提供基础数据。方法选择该院2011年1月—2014年1月收治的经胃镜检查确诊为胃癌的黄州地区居民患者438例为研究组，选取同期于该院行胃镜检查、性别、年龄及生源地按1∶1配对的慢性胃炎患者作对照组，使用该院设计的问卷对两组患者进行调查研究，对调查数据进行单因素与多因素条件Logistic回归分析，比较慢性胃炎患者与胃癌患者之间影响因素的差异，找到胃癌发病的独立危险因素。结果观察组胃癌与对照组慢性胃炎患者各438例纳入研究，对单因素条件Logistic回归分析差异有统计学意义的影响因素（P＜0．05）进一步做多因素条件Logistic回归分析，结果显示饮水来源、吸烟、经常吃腌制食品、有胃溃疡疾病史、近亲有胃癌疾病史及上消化道症状反复时间为胃癌发病的独立危险因素，运动及间断使用抑酸或制酸药为胃癌发病的独立保护因素。结论环境因素、饮食习惯及遗传因素均可能是慢性胃炎发展为胃癌的影响因素，但其影响作用尚存争议需进一步研究。

Influence factors of gastric cancer and chronic gastritis in Huangzhou area:A matched case-control study

Objective To analyze the related impact factors of gastric cancer and chronic gastritis in Huangzhou area,and provide basic data for the predisposing factors and prevention measures of gastric cancer.Methods 438 cases diagnosed of gastric cancer by endos-copy in our hospital from January 201 1 to January 2014 in Huangzhou area were treated as the observation group,while chronic gastritis patients treated during the same period in our hospital were selected as the control group.These two groups were surveyed by question-naire,and single-factor and multiple-factor logistic regression analyses were applied to analyze the obtained data.Factors were compared between these two groups to find the independent risk factors for gastric cancer.Results 438 cases from the observation group and the control group were respectively included in the study.Multiple-factor logistic regression analysis was performed on factors which showed statistically significant difference (P<0.05)in single-factor logistic regression analysis,showing that drinking water sources,smoking, pickled food,stomach ulcer disease history,gastric disease history of close relatives and recurrent symptoms of upper digestive tract are independent risk factors of gastric cancer.It also found exerciseand intermittent acid or acid drugs use are the independent protective factors of gastric cancer.Conclusions Environmental factors,dietary habits and genetic factors were likely to be the factors that chron-ic gastritis develops into gastric cancer,but its role remains controversial,which needs further study.