血清NSE对晚期早产儿窒息脑损伤早期评价的意义

目的探讨新生儿窒息后血清神经元特异性烯醇化酶（NSE）水平变化对判断晚期早产儿脑损伤的价值。方法选取154例晚期早产儿为研究对象,其中出生时有窒息的患儿94例为实验组,于出生后3～7 d行颅脑MRI检查,依据颅脑MRI分为无脑损伤组42例和脑损伤组52例;正常的60例为对照组,所有患儿均在其出生后24 h内检测血清NSE浓度。结果窒息脑损伤组血清NSE值较窒息无脑损伤组和对照组增高,差异具有统计学意义（P〈0.05）,窒息无脑损伤组血清NSE值较对照组增高,但差异无统计学意义（P〉0.05）。结论外周血清NSE值可作为临床早期评价晚期早产儿窒息后脑损伤的参考指标。

Significance of serum neuron-specific enolase in the early evaluation of brain damage of late preterm with perinatal asphyxia

Objective To investigate the value of serum neuron-specific enolase（NSE）levels in the diagnosis of neonatal asphyxia Methods 154 late-preterm neonates were enrolled in the study,including 94 with neonatal asphyxia for experimental group,52 with perinatal asphyxia,42 without brain damage and 60 normal ones for control group.For all the research objects blood samples were obtained for NSE detecting and Apgar scores were evaluated on proper time.MRI was performed 3~7 days after birth in experimental group. Results The levels of serum NSE in 52 with perinatal asphyxia were significantly higher than those in ones without brain damage and in control group.There were no significant difference between the levels in ones without brain damage and in control group.Conclusion Serum NSE level can be used as the early objective markers for evaluating the prognosis of brain damage due to late preterm perinatal asphyxia.