骨质疏松症与血管钙化的相关性研究进展

骨质疏松症( OP)是以骨的微结构破坏、骨量减少、脆性增加、易发生骨折为特征的全身代谢性骨病。血管钙化( VC)是动脉粥样硬化的主要表现形式，是心血管疾病的主要病理基础。 OP与 VC的影响因素众多且复杂，该研究将从两方面讨论 OP与 VC的相关性:在临床上，老龄化、雌激素水平降低、血脂异常、高血糖、甲状旁腺激素上升、维生素 D3下降可导致 OP的同时也可促进 VC；在共同分子作用机制层面，骨保护素( OPG)、骨形态发生蛋白( BMP)、基质 Gla蛋白( MPG)、 Klotho因子( Klotho)、胎球蛋白 -A(FITUIN-A)表达抑制可导致 OP同时也可促进 VC，而 Wnt信号通路(Wnt)表达增加、骨桥蛋白( OPN)表达下降可以改善 OP但是会导致 VC。

Study on the relationship between osteoporosis and vascular calcification

Osteoporosis (OP) is a systemic metabolic bone disease characterized by the destruction of bone microstructure, decreasedbone mass, increased fragility and susceptibility to fractures. Vascular calcification (VC) is the main manifestation of atherosclerosisand the main pathological basis of cardiovascular disease. The influencing factors of osteoporosis and vascular calcification are numer.ous and complex. In this review, we will discuss the relationship between osteoporosis and vascular calcification from two aspects: clini.cally, aging, decreased estrogen levels, dyslipidemia, high Increased blood sugar, parathyroid hormone, and decreased vitamin D3 canlead to osteoporosis and promote vascular calcification; at the level of common molecular mechanisms, inhibition of the expression ofOPG, BMP, MPG, Klotho, and FITUIN-A can lead to osteoporosis at the same time. It can also promote vascular calcification, while in.creased Wnt expression and decreased OPN expression can improve osteoporosis but lead to vascular calcification.