| XELOX与FLO方案治疗晚期胃癌的近期疗效及毒副反应比较 |
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| 引用本文： | 王磊,胡冰,季楚舒,胡长路,何义富,单本杰.XELOX与FLO方案治疗晚期胃癌的近期疗效及毒副反应比较[J].安徽医药,2011,15(3):329-330. |
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| 作者姓名： | 王磊 胡冰 季楚舒 胡长路 何义富 单本杰 |
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| 作者单位： | 安徽医科大学附属省立医院肿瘤科,安徽,合肥,230001;安徽医科大学附属省立医院肿瘤科,安徽,合肥,230001;安徽医科大学附属省立医院肿瘤科,安徽,合肥,230001;安徽医科大学附属省立医院肿瘤科,安徽,合肥,230001;安徽医科大学附属省立医院肿瘤科,安徽,合肥,230001;安徽医科大学附属省立医院肿瘤科,安徽,合肥,230001 |
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| 摘 要： | 目的比较奥沙利铂联合卡培他滨方案(XELOX)与奥沙利铂联合5-FU/LV(FLO)方案治疗的晚期胃癌的近期疗效和毒副反应。方法通过查阅病例资料回顾分析2007年5月～2009年4月期间该科收治的62例采用XELOX和FLO化疗方案治疗的晚期胃癌,其中奥沙利铂联合卡培他滨(XELOX)A组33例,奥沙利铂联合5-FU/LV(FLO组)B组29例。结果 A组总有效率48.48%,疾病进展时间5.92个月,B组为44.83%和5.70个月,两组之间差异无统计学意义;A组中性粒细胞减少发生率15.2%,明显低于B组48.3%(P=0.006<0.01);A组神经毒性发生率15.2%明显低于B组58.6%(P=0.000<0.01);A组的手足综合症发生率(48.5%)明显高于B组13.8%(P=0.006<0.01),大多数为轻度,主要为I～Ⅱ度。结论 XELOX方案与FLO方案的疗效相近,但XELOX方案毒副反应较轻、耐受性良好、临床使用方便等优点。
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| 关 键 词： | 晚期胃癌 疗效 毒副反应 卡培他滨 奥沙利铂 |
Combination chemotherapy with XELOX and FLO:a comparison in the treatment of advanced gastric cancer |
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| WANG Lei,HU Bing,JI Chu-shu,HU Chang-lu,HE Yi-fu,SHAN Ben-jie.Combination chemotherapy with XELOX and FLO:a comparison in the treatment of advanced gastric cancer[J].Anhui Medical and Pharmaceutical Journal,2011,15(3):329-330. |
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| Authors: | WANG Lei HU Bing JI Chu-shu HU Chang-lu HE Yi-fu SHAN Ben-jie |
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| Institution: | WANG Lei,HU Bing,JI Chu-shu,HU Chang-lu,HE Yi-fu,SHAN Ben-jie(Department of Oncology,Anhui Provincial Hosptial Affiliated to Anhui Meidical University,Hefei,Anhui 230001,China) |
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| Abstract: | Aim To evaluate the comparison of the near efficacy and toxicity of oxaliplatin combined with capecitabine program(XELOX)with oxaliplatin in combination with 5-FU/LV(FLO)in the treatment of advanced gastric cancer.Methods From May 2007 to April 2009,treatment of advanced gastric cancer with XELOX was retrospectively analyzed and compared with that with FLO.62 patients were divided into two groups,group A(XELOX)33 patients and group B(FLO)29 patients.Results The overall response rate was 48.48% and time to d... |
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| Keywords: | advanced gastric cancer efficacy toxicity capecitabine oxaliplatin |
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