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HPLC法测定小儿七星茶口服液有效成分的含量
引用本文:蒋永和,袁继承,李卓亚,沈志滨,张景亮.HPLC法测定小儿七星茶口服液有效成分的含量[J].安徽医药,2009,13(11):1337-1339.
作者姓名:蒋永和  袁继承  李卓亚  沈志滨  张景亮
作者单位:广东药学院中药化学与分析教研室,广东,广州,510006;广东药学院中药化学与分析教研室,广东,广州,510006;广东药学院中药化学与分析教研室,广东,广州,510006;广东药学院中药化学与分析教研室,广东,广州,510006;广东药学院中药化学与分析教研室,广东,广州,510006
摘    要:目的为制定小儿七星茶口服液的定量标准提供参考。方法采用高效液相色谱法测定有效成分钩藤碱和甘草苷的含量。结果钩藤碱在0.0258-0.258μg范围内有良好的线性关系,线性回归方程:y=1486205x-3621,r^2=0.9999;精密度、重复性、稳定性、回收率的RSD分别为0.12%、2.5%、1.5%、2.4%,样品平均含量达1.405 mg.L^-1。甘草苷在1.346-4.093μg范围内有良好的线性关系,线性回归方程:y=3E+7x-37274,r^2=0.999;精密度、重复性、稳定性、回收率的RSD分别为2.63%、4.02%、2.71%、0.55%,样品平均含量达129.28 mg.L^-1。结论采用高效液相色谱法测定钩藤碱和甘草苷的含量可以作为小儿七星茶口服液的定量标准。

关 键 词:小儿七星茶  高效液相色谱  钩藤碱  甘草苷

Determination of effective components in xiao′erqixingcha oral liquid by HPLC
JIANG Yong-he,YUAN Ji-cheng,LI Zhuo-ya,SHEN Zhi-bin,ZHANG Jing-liang.Determination of effective components in xiao′erqixingcha oral liquid by HPLC[J].Anhui Medical and Pharmaceutical Journal,2009,13(11):1337-1339.
Authors:JIANG Yong-he  YUAN Ji-cheng  LI Zhuo-ya  SHEN Zhi-bin  ZHANG Jing-liang
Institution:JIANG Yong-he,YUAN Ji-cheng,LI Zhuo-ya,SHEN Zhi-bin,ZHANG Jing-liang(Section of TCM Chemistry , Analysis,Guangdong College of Pharmacy,Guangzhou 510006)
Abstract:Aim To develop xiao′erqixingcha oral liquid quantitative standards for reference.Methods Determination of effective components rhynchophylline and liquiritin by HPLC.Results Rhynchophylline had a good linear relationship at 0.0258 - 0.258 μg the linear regression equation:y=1486205x-3621,r^2=0.9999;for precision,reproducibility,stability recovery,the RSD were 0.12%,2.5%,1.5%,2.4% respectively,the average content of samples was 1.405 mg·L^-1.Liquiritin had a good linear relationship in 1.34~4.093 μg the linear regression equation :y = 3E + 7x - 37274, r^2 = 0. 999 ; for precision, reproducibility, stability, recovery, RSD were 2.63 % ,4.02% ,2.71% ,0.55%, respectively the average content of samples was 129.28 mg · L^-1 Conclusion Determination of effective components rhynchophylline and Liquiritin by HPLC can be used as xiaoo qixingcha oral liquid quantitative standards.
Keywords:xiao\'er qixingcha  HPLC  rhynchophylline  liquiritin  
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