玉屏风颗粒联合复合脉冲磁疗治疗小儿肺炎恢复期肺脾气虚证的临床观察

目的 探讨玉屏风颗粒联合复合脉冲磁疗治疗小儿肺炎恢复期肺脾气虚证的临床效果及对T淋巴细胞亚群的影响.方法 将100例小儿肺炎恢复期肺脾气虚证患儿采用随机数字表法分为治疗组和对照组各50例,对照组给抗生素抗感染、止咳、平喘治疗,治疗组在此基础上给予玉屏风颗粒联合复合脉冲磁疗进行治疗,观察两组治疗效果及T淋巴细胞亚群变化情况.结果 治疗组患儿咳少痰多消失时间(4.86±0.56)d、面色少华消失时间(5.34±1.42)d、神疲倦怠消失时间(4.86±1.05)d、食少纳呆消失时间(4.23±1.06)d以及大便稀溏消失时间(4.64±1.03)d均明显短于对照组患儿(5.67±1.86)、(7.36±1.56)、(6.45±1.43)、(5.34±1.24)、(5.64±1.56)d(P＜0.01);治疗组CD3+T、CD4 +T和CD4+ T/CD8+T比值治疗后水平均明显高于治疗前和治疗后的对照组(P＜0.05),而CD8+T水平均明显低于治疗前和治疗后的对照组(P＜0.05),两组患儿均未发生明显的不良反应.结论 玉屏风颗粒联合复合脉冲磁疗治疗小儿肺炎恢复期肺脾气虚证临床疗效确切,改善患儿的免疫功能紊乱可能是作用机制之一.

The clinical observation of treating the Qi deficiency of spleen and lung during infantile pneumonia convalescence with Yupingfeng granule combined with complex pulse magnetic

Objective To observe the clinical effect and influence on the T lymphocyte subpopulations level of Yupingfeng granule combined with complex pulse magnetic therapy Qi deficiency of spleen and lung during infantile pneumonia convalescence.Methods Randomly divided 100 patients with the syndrome of Qi deficiency of spleen and lung during infantile pneumonia convalescence were divided into the treatment group and the control group randomly.There were 50 cases in each group,gave anti-infection treatment,cough-relieving treatment and antiasthmatic treatment to both groups,and an extra treatment of Yupingfeng granule combined with complex pulse magnetic in the treatment group.The efficacy and the changes of lymphocyte subpopulations level in two groups were observed.Results The disappearance time of less cough excessive phlegm (4.86 ± 0.56) d,the disappearance time of pale complexion (5.34 ± 1.42) d,the disappearance time of food less poor appetite,(4.23 ± 1.06) d and the disappearance time of thin sloppy stool (4.64 ± 1.03) d of the patients in the treatment group were significantly shorter than those of the patients in the control group (5.67 ± 1.86),(7.36 ± 1.56),(6.45 ± 1.43),(5.34 ± 1.24),(5.64 ± 1.56) d,the difference was statistically significant (P ＜ 0.05).CD3 +,CD4 + and CD4 +/CD8 + level in the treatment group were significantly higher than those before the treatment and those in the control group after the treatment (P ＜ 0.05).The level of CD8 + were significantly lower than control group before and after treatment (P ＜ 0.05).There was no obvious adverse reaction observed in both groups.Conclusions Qi deficiency of spleen and lung during infantile pneumonia convalescence with Yupingfeng Granule combined with complex pulse magnetic treatment has definitely curative effect,which improve immune function disorder may be one of the functional mechanism.