腺样体肥大或伴扁桃体肥大的睡眠呼吸障碍儿童平均血小板体积和血小板分布宽度变化的临床意义

目的 探讨腺样体肥大或伴扁桃体肥大的睡眠呼吸障碍(SDB)儿童的平均血小板体积(MPV)和血小板分布宽度(PDW)变化的临床意义。方法 选择2018年1月至2019年1月安徽医科大学附属巢湖医院耳鼻咽喉-头颈外科住院患儿99例,均诊断为SDB(腺样体肥大或伴扁桃体肥大),设为病例组。另选取同时期因SDB以外原因(包括先天性耳前瘘管,鼻骨骨折,先天性鳃裂瘘管,颈部良性肿瘤,外耳道异物)而收住入院的51例患儿为对照组,并经过仔细询问病史,否认有SDB,体格检查均无腺样体肥大或伴有扁桃体肥大。记录病例组与对照组的血常规各项指标数值,比较两组血常规相关指标的差异。结果 病例组平均血小板体积(MPV)为(10.89±1.30)fL,对照组为(11.38±1.28)fL,差异有统计学意义(P<0.05)。对照组血小板分布宽度(PDW)为13.60(12.00,15.90)]fL,病例组为12.70(10.85,15.35)]fL,差异有统计学意义(P<0.05)。其余血常规指标在病例组与对照组间差异均无统计学意义(P>0.05)。Pearson积差相关分析显示,病例组的MPV和PDW均与年龄呈正相关,Spearman秩相关显示,MPV和PDW均与腺样体肥大等级呈负相关。结论 MPV和PDW可能作为判断腺样体肥大或伴有扁桃体肥大SDB患儿病情严重程度的潜在指标。

Clinical significance of mean platelet volume and platelet distribution width in children with sleep-disordered breathing

Objective To analyze the clinical significance of mean platelet volume (MPV) and platelet distribution width (PDW) changes in children with sleep-disordered breathing(SDB) (adenoid hypertrophy or with tonsil hypertrophy). Methods This case-control study enrolled 99 inpatients cases and 51 controls in the Department of Otolaryngology Head and Neck Surgery of Chaohu Hospital affiliated to Anhui Medical University (from January 2018 to January 2019).A total of 99 inpatients were set as case group which were diagnosed as SDB (adenoid hypertrophy or with tonsil hypertrophy). Fifty-one pediatric patients hospitalized for reasons other than SDB (including congenital anterior ear fistula, nasal bone fracture, congenital gill fissure fistula, benign neck tumor, foreign body in external auditory meatus) were included in control group. The blood routine indicators of case group and control group were recorded and analized by T test, Mann Whitney U test, Pearson correlation and Spearman correlation.Results MPV level in case group was (10.89±1.30) fL, and MPV level incontrol group was (11.38±1.28) fL. MPV level in case group was lower than that in control group (P<0.05). PDW levels were 13.60 (12.00, 15.90)] fL in control group and 12.70 (10.85, 15.35)] fL in case group. PDW level in case group was lower than that in control group (P<0.05). There was no significant difference in the remaining blood routines between case group and control group (P>0.05). MPV and PDW of case group were positively correlated with age and negatively correlated with the grade of adenoid hypertrophy. Conclusion MPV and PDW may be used as potential indicators of the severity in SDB children with adenoid hypertrophy or with tonsil hypertrophy.