| 胃滞留给药系统的研究开发进展 |
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| 引用本文： | 王凤娟,包泳初,陈庆华.胃滞留给药系统的研究开发进展[J].上海医药,2012,33(3):24-28. |
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| 作者姓名： | 王凤娟 包泳初 陈庆华 |
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| 作者单位： | 中国医药工业研究总院,药物制剂国家工程研究中心,上海,200437 |
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| 摘 要： | 胃滞留型缓释给药系统可增加"窄吸收窗"药物的滞留时间、提高其生物利用度、增加患者顺应性等优点。近二三十年来各国学者对该类新型制剂开展了大量研究,取得不少进展。本文拟对漂浮型、黏附型以及膨胀型三种胃滞留缓释给药系统的设计思路、辅料应用、体内外释放行为等进行简要的介绍和评价,为胃滞留型缓释给药系统的研究开发提供科学依据。
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| 关 键 词： | 胃滞留剂型 胃漂浮给药系统 胃黏附给药系统 胃膨胀给药系统 药动学 |
R & D advances of gastro-retentive drug delivery system |
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| WANG Fen-juan,BAO Yong-cu,CHEN Qin-hua.R & D advances of gastro-retentive drug delivery system[J].Shanghai Medical & Pharmaceutical Journal,2012,33(3):24-28. |
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| Authors: | WANG Fen-juan BAO Yong-cu CHEN Qin-hua |
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| Institution: | WANG Fen-juan, bAO Yong-cu, CHEN Qin-hua(National Pharmaceutical Engineering and research Center,China State Institute of Pharmaceutical Industry,Shanghai,201203) |
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| Abstract: | Gastroastro-retentive drug delivery system can extend acting time,improve bioavailability and patient’ s compliance for drugs with a narrow absorption window in the upper gastrointestinal tract. The design idea,excipients incorporated and drug release in vitro and in vivo are reviewed in this paper to provide the scientific basis for r D of gastro-retentive dosage forms. |
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| Keywords: | gastro-retentive dosage forms floating systems bioadhesive systems expandable systems pharmacokinetics |
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