|
|||||
|
|
| 注射用生长抑素在输液配伍中的稳定性考察 | |
| 引用本文： | 王莉英,蒋军,陈荣,吉莉娜,徐燕妮.注射用生长抑素在输液配伍中的稳定性考察[J].上海医药,2010,31(11):507-509. |
| 作者姓名： | 王莉英 蒋军 陈荣 吉莉娜 徐燕妮 |
| 作者单位： | 1. 江苏省常州市第一人民医院药剂科,常州,213003 2. 南京医科大学临床药学系,南京,211166 3. 南京中医药大学药学系,南京,210046 |
| 摘 要： | 目的：考察注射用生长抑素在临床常用输液配伍中的稳定性。方法：室温下将注射用生长抑素与不同输液混合,采用高效液相色谱法测定生长抑素24h内含量变化情况,同时考察配伍液的外观和pH值变化。结果：生长抑素的稳定性与时间及输液中的电解质有关。在5%葡萄糖注射液中,生长抑素在12h内稳定,24h后稳定性有所下降。结论：注射用生长抑素宜与5%葡萄糖注射液配伍使用,而不宜与含钾电解质溶液配伍使用。 |
| 关 键 词： | 生长抑素 高效液相色谱法 稳定性 |
Compatible stability of Somatostatin for injection with infusion solutions |
|
| WANG Li-ying,Jiang Jun,Chen Rong,JI Li-na,XU Yan-ni.Compatible stability of Somatostatin for injection with infusion solutions[J].Shanghai Medical & Pharmaceutical Journal,2010,31(11):507-509. | |
| Authors: | WANG Li-ying Jiang Jun Chen Rong JI Li-na XU Yan-ni |
| Institution: | 1.Dept.of Pharmacy,The First People＇s Hospital of Changzhou,Changzhou,213003;2.Dept.of Clinical Pharmacy,Nanjing Medical College,Nanjing,211166;3.Dept.of Pharmacy,Nanjing University of Tradational Chinese Medicine,Nanjing,210046) |
| Abstract: | Objective：To study the compatible stability of somatostatin with usual infusion solutions.Methods：Somatostatin with different infusion solutions was mixed in the condition of room temperature and the changes of the external appearances and pH values of the mixed solutions was observed by using a pH meter at 25℃;the content changes of somatostatin for injection was measured by using HPLC in 24 hours.Results：Stability was related to time and electrolyte.At 25℃,somatostatin in 5% glucose injection could be used for 12 hours.The stability descended when it was used for 24 hours.Conclusion：Somatostatin in 5% glucose injection can be combined used,but it is not suitable to combined use with potassium electrolyte solution. |
| Keywords: | somatostatin HPLC stability |
| 本文献已被 维普 万方数据 等数据库收录！ | |