观察小剂量氯胺酮与中剂量戊巴比妥对幼猪心内直视手术的复合麻醉效果

目的观察小剂量氯胺酮(静脉麻醉药)与中剂量戊巴比妥(镇静、催眠药)对幼猪心内直视手术的复合麻醉效果。方法幼猪30例,肌注氯胺酮3 mg.kg-1和戊巴比妥20 mg.kg-1诱导插管;分别静注氯胺酮、戊巴比妥钠、咪达唑仑、哌库溴铵5,6~8,0.1~0.2,0.1 mg.kg-1.h-1,维持麻醉,转机后停用戊巴比妥;记录各期生命体征、血流动力学和动脉血气分析参数等指标的变化。结果30例于各期血流动力学稳定,麻醉诱导和麻醉维持时间分别为(9±2),(179±15)m in;2例分别在诱导期和拔管后,出现呼吸心跳骤停,均抢救成功;诱导和维持效果达Ⅰ级者分别占73.3%和80.0%。结论小剂量氯胺酮和中剂量戊巴比妥有利于改善呼吸和循环抑制,联合用药兼备镇静和镇痛效果,可达到很好地外科麻醉效果。

Observation of combination anesthesia with low-dose ketamine and mid-dose pentobarbital for open heart surgeryin juvenile pigs

Objective To investigate combination anesthesia with low-dose ketamine and mid-dose pentobarbital for open heart surgery in ju-venile pigs.Methods Thirty experimental juvenile pigs received ket-amine(3 mg·kg~(-1))and pentobarbital(20 mg·kg~(-1))intramuscularly for induction and intubation,then were given ketamine(5 mg·kg~(-1)·h~(-1)),pentobarbital(6-8 mg·kg~(-1)·h~(-1)),midazolam(0.1-0.2mg kg~(-1)·h~(-1))and pipecuronium(0.1 mg·kg~(-1)·h~(-1))intravenously for maintenance.The infusion of pentobarbital was withdrawn after car-diopulmonary bypass started.During the experimental treatment,vital signs were monitored;artery gas analysis and hemodynamie parameters were recorded.Results Twenty-eight juvenile pigs got stable hemody-namic parameters in the perioperative period.The time of anesthetic in-duction and maintenance is(9±2)and(179±15)min,respectively.The respiratory and cardiac arrest rates were 6.7% in induction and 3.3% in maintenance.respectively.Two cases got respiratory and cardi-ac arrest.on in induction and the OtIler after extubation.In addition,class I anesthetic effectiveness was achieved 73.3% in induction and 80.0% in maintenance,respectively.Conclusion This study demon-strated that lOW-dose ketamine combined with mid-dose pentobarbihal has little inhibition on respiration and circulation.The combination can achieve both hypnosis and analgesia effects with good surgical anesthetic effectiveness in juvenile pigs with open heart surgery.