| 卫生部全国细菌耐药监测网(Mohnarin)2009年度报告:ICU来源细菌耐药监测 |
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| 引用本文： | 陈宏斌,张小江,赵颖,徐英春,吕媛.卫生部全国细菌耐药监测网(Mohnarin)2009年度报告:ICU来源细菌耐药监测[J].中国临床药理学杂志,2011,27(7). |
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| 作者姓名： | 陈宏斌 张小江 赵颖 徐英春 吕媛 |
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| 作者单位： | 1. 中国医学科学院 北京协和医院 检验科,北京,100730
2. 北京大学第一医院 临床药理研究所,北京,100034 |
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| 摘 要： | 目的了解全国不同地区ICU病房分离细菌病原谱及其对常用抗菌药物的耐药性。方法全国114家医院ICU分离细菌,按照统一方案进行抗菌药物敏感性试验,并按照CLSI 2010版判断结果。结果 2009年度收集各医院ICU分离细菌共8931株,其中革兰阳性菌占26.4%,革兰阴性菌占73.6%。金黄色葡萄球菌和凝固酶阴性葡萄球菌中,甲氧西林耐药株的发生率分别为72.4%,95.4%。葡萄球菌属中,甲氧西林耐药株对β内酰胺类和其他抗菌药物的耐药率显著高于甲氧西林敏感株。对葡萄球菌属较为敏感的药物有磷霉素、复方磺胺、利福平和阿米卡星;未发现对万古霉素、替考拉宁和利奈唑胺耐药株。ICU分离的屎肠球菌(n=344)多于粪肠球菌(n=141),并且屎肠球菌对大多数抗菌药物的耐药率高于粪肠球菌。粪肠球菌对氨苄西林(26.1%)和呋喃妥因(17.2%)的耐药率较低;两者均出现了对万古霉素耐药菌株;未发现利奈唑胺耐药株。大肠埃希菌、肺炎克雷伯菌和产酸克雷伯菌中,产ESBLs酶菌株的发生率分别为73.8%,64.1%和63.6%;产ESBLs酶菌株对抗菌药物的耐药率均比非产ESBLs酶菌株高。肠杆菌科细菌中,已经出现了少数对碳青酶烯类...
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| 关 键 词： | 细菌耐药性监测 抗菌药物敏感性试验 多重耐药菌 泛耐药菌 |
National Antimicrobial Resistant Investigation Net(Mohnarin) 2009 annual report:Antimicrobial resistance surveillance in intensive care units |
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| CHEN Hong-bin,ZHANG Xiao-jiang,ZHAO Ying,XU Ying-chun,LV Yuan.National Antimicrobial Resistant Investigation Net(Mohnarin) 2009 annual report:Antimicrobial resistance surveillance in intensive care units[J].The Chinese Journal of Clinical Pharmacology,2011,27(7). |
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| Authors: | CHEN Hong-bin ZHANG Xiao-jiang ZHAO Ying XU Ying-chun LV Yuan |
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| Institution: | CHEN Hong-bin1,ZHANG Xiao-jiang1,ZHAO Ying1,XU Ying-chun1,LV Yuan2 (1.Department of Laboratory Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China,2.Institute of Clinical Pharmacology,First Hospital,Peking University,Beijing 100034,China) |
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| Abstract: | Objective To investigate antimicrobial resistance among clinical isolates from ICU in several regions of China.Methods One hundred and fourteen hospitals were involved in this program.Antimicrobial susceptibility testing was carried out according to a unified protocol.Results A total of 8931 clinical isolates from ICU were collected from January to December 2009,of which gram positive cocci and gram negative organisms accounted for 26.4% and 73.6% respectively.Methicillin resistant strains in S.aureus(MRSA)... |
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| Keywords: | bacterial resistance surveillance antimicrobial susceptibility test multi-drug resistant bacteria pan-resistant bacteria |
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