|
|||||
|
|
| 大蒜素联合不同药物对多重耐药鲍曼不动杆菌的体外抗菌作用 | |
| 引用本文： | 李贵玲,刘根焰,陈寅,顾兵,梅亚宁,童明庆,潘世扬,王虹. 大蒜素联合不同药物对多重耐药鲍曼不动杆菌的体外抗菌作用[J]. 中国临床药理学杂志, 2011, 27(10) |
| 作者姓名： | 李贵玲 刘根焰 陈寅 顾兵 梅亚宁 童明庆 潘世扬 王虹 |
| 作者单位： | 1. 南京医科大学第一附属医院,医学检验科,南京210029;扬州大学临床医学院临床医学检测中心,江苏扬州225001 2. 南京医科大学第一附属医院,医学检验科,南京210029 3. 江苏大学 4. 南京医科大学第一附属医院,呼吸科,南京210029 |
| 基金项目： | 科技部“全国科技支疆行动”合作基金资助项目; 卫生部国家临床重点专科基金资助项目 |
| 摘 要： | 目的评价大蒜素单用及其联合亚胺培南或头孢哌酮/舒巴坦对多耐药鲍曼不动杆菌的体外抗菌作用。方法用微量肉汤稀释法,分别测定大蒜素、亚胺培南、头孢哌酮/舒巴坦对30株多耐药鲍曼不动杆菌的最低抑菌浓度(MIC);同时测定大蒜素与亚胺培南、大蒜素与头孢哌酮/舒巴坦组合药物对该菌株的MIC,计算出部分抑菌浓度指数(FICI)。结果大蒜素单药对鲍曼不动杆菌的MICrange为16～64μg.mL-1,MIC50为32μg.mL-1,MIC90为32μg.mL-1。大蒜素联合亚胺培南和大蒜素联合头孢哌酮/舒巴坦的FICI范围均为0.31～1.50。结论大蒜素单药对鲍曼不动杆菌有明显的体外抑菌作用;亚胺培南和头孢哌酮/舒巴坦均可增强大蒜的体外抗菌活性。 |
| 关 键 词： | 大蒜素 鲍曼不动杆菌 棋盘法 微量肉汤稀释法 |
Antibacterial activity in vitro of allicin alone and in combination with imipenem or cefperazone-sulbactam against multidrug-resistant Acinetobacter baumannii |
|
| LI Gui-ling,LIU Gen-yan,CHEN Yin,GU Bing,MEI Ya-ning,TONG Ming-qing,PAN Shi-yang,WANG Hong. Antibacterial activity in vitro of allicin alone and in combination with imipenem or cefperazone-sulbactam against multidrug-resistant Acinetobacter baumannii[J]. The Chinese Journal of Clinical Pharmacology, 2011, 27(10) | |
| Authors: | LI Gui-ling LIU Gen-yan CHEN Yin GU Bing MEI Ya-ning TONG Ming-qing PAN Shi-yang WANG Hong |
| Affiliation: | LI Gui-ling1a,2,LIU Gen-yan1a,CHEN Yin,GU Bing1a,MEI Ya-ning1a,TONG Ming-qing1a,PAN Shi-yang1a,WANG Hong1b (1.a.Department of Laboratory,b.Department of Respiratory,The First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,China,2.Department of Laboratory Medicine,Affiliated Hospital to Yangzhou University,Yangzhou 225001,Jiangsu Province,China) |
| Abstract: | Objective To evaluate the activity in vitro of allicin alone and allicin combined with imipenem(IMP) or cefperazone-sulbactam(SCF) on multidrug-resistant Acinetobacter baumannii.Methods Thirty strains of multidrug-resistant Acinetobacter baumannii clinical isolates were selected randomly in the First Hospital Affiliated to Nanjing Medical University from January 2010 to June 2010.Broth microdilution method was used to measure the minimum inhibitory concentration(MIC) of allicin,IMP,and SCF against the Acine... |
| Keywords: | allicin Acinetobacter baumannii checkerboard method broth microdilution method |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |