| 聚乙烯亚胺非病毒基因载体结构修饰研究进展 |
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| 作者姓名： | 林浩 何东升 涂家生 |
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| 作者单位： | 中国药科大学药学院，江苏 南京 210009,中国药科大学药学院，江苏 南京 210009,中国药科大学药学院，江苏 南京 210009 |
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| 基金项目： | 国家科技重大专项（No.2017X09101001）；江苏省自然科学基金（No.BK20180553） |
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| 摘 要： | 聚乙烯亚胺（PEI）作为最经典的非病毒基因载体之一，由于其高转染效率，在基因递送领域受到极大的关注，但其毒性限制了聚乙烯亚胺的应用。本文综述了对聚乙烯亚胺进行不同的结构修饰，如多糖修饰、PEG修饰和低分子聚乙烯亚胺衍生物等，以实现在不显著降低转染效率的前提下减少细胞毒性。
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| 关 键 词： | 聚乙烯亚胺 非病毒基因载体 结构修饰 基因转染 细胞毒性 |
Development of polyethyleneimine as non-viral gene vectors in structural modification |
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| Authors: | LIN Hao HE Dongsheng and TU Jiasheng |
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| Institution: | School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China and School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Polyethylenimine (PEI), as one of the most classic non-viral gene vectors, has received great attention in the field of gene delivery due to its high transfection efficiency,but its toxicity limits the application of PEI. This paper reviewed the development of different structural modifications of PEI, such as polysaccharide modified PEI, PEG modified PEI,low molecular PEI derivatives,to potentially reduce cytotoxicity without significantly sacrificing transfection efficiency. |
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| Keywords: | Polyethyleneimine Non-viral gene carrier Structural modification Gene transfection Cytotoxicity |
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