心肌缺血模型的制作方法研究进展

心肌缺血(myocardial ischemia)是心脏的血液灌注减少,导致心脏的供氧减少,心肌能量代谢异常,不能支持心脏正常工作的一种病理状态。心血管疾病康复机制研究的关键技术之一是复制心肌缺血动物模型。建立适当的动物模型,不仅为该病的发病机制和病理生理改变提供重要的资料,更重要的是能促进新药的开发,推进临床诊断和各种治疗方法的进步。该文全面总结归纳了急性心肌缺血、慢性心肌缺血、可控性心肌缺血和离体心肌缺血四类心肌缺血模型的制作方法以及各自的特点,为该疾病模型的制作与选择提供参考。

Progress in preparation methodology of animal models of myocardial ischemia

Myocardial ischemia is a pathological state of heart not working properly caused by the reduction of cardiac blood perfusion,which leads to the decrease of the heart’s oxygen supply and the abnormality of the myocardial energy metabolism.The replication of animal models of myocardial ischemia is one of the key technologies of rehabilitation mechanisms of cardiovascular disease.The establishment of appropriate animal models not only provides important information for the pathogenesis of the disease and pathophysiological changes,but more importantly,promotes the development of new drugs and the progress of clinical diagnosis and treatment.This paper provides a comprehensive summary of the recent myocardial ischemia models including acute,chronic,controllable and myocardial ischemia in vitro and a guidance on the replication and selection of the disease model.