| 奥丹西隆对小鼠吗啡身体依赖性的影响 |
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| 引用本文： | 谢和辉,徐美林,余涓,陈崇宏,俞昌喜.奥丹西隆对小鼠吗啡身体依赖性的影响[J].中国药理学通报,2003,19(1):56-59. |
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| 作者姓名： | 谢和辉 徐美林 余涓 陈崇宏 俞昌喜 |
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| 作者单位： | 福建医科大学药理学教研室,福州,350004 |
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| 基金项目： | 福建省自然科学基金资助项目 No 94A0 0 6 |
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| 摘 要： | 目的 观察 5 HT3受体特异性拮抗剂奥丹西隆 (on dansetron ,Ond)对吗啡身体依赖性的影响。方法 采用小鼠吗啡依赖模型及离体豚鼠回肠吗啡依赖模型。结果 奥丹西隆 12d预防性给药可有效抑制小鼠吗啡戒断反应 ,使其体重降低减小 (Ond 2～ 10 0 μg·kg-1·d-1组 ) ,或体重降低 ,跳跃反应均明显减弱 (Ond 10 0 μg·kg-1·d-1组 )。另外 ,奥丹西隆 (1～ 2 0 μmol·L-1)亦可抑制纳洛酮促发的离体豚鼠回肠收缩。作用均呈剂量依赖性。结论 奥丹西隆预防性的慢性给药可在一定程度上抑制吗啡身体依赖的形成
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| 关 键 词： | 奥丹西隆 吗啡 身体依赖 豚鼠回肠 |
| 文章编号： | 1001-1978(2003)01-0056-04 |
| 修稿时间： | 2002年3月20日 |
Effects of ondansetron on morphine physical dependence in mice |
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| XIE He Hui,XU Mei Lin,YU Juan,CHEN Chong Hong,YU Chang Xi.Effects of ondansetron on morphine physical dependence in mice[J].Chinese Pharmacological Bulletin,2003,19(1):56-59. |
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| Authors: | XIE He Hui XU Mei Lin YU Juan CHEN Chong Hong YU Chang Xi |
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| Abstract: | AIM To investigate the effects of ondansetron, a selective 5 Hydroxytryptamine3 (5 HT 3) receptor antagonist, on morphine physical dependence. METHODS The morphine dependent models in mice and in isolated Guinea pig ileum were used. RESULTS Pretreatment of ondansetron for 12 days significantly reduced morphine withdrawal symptoms in mice ,such as body weight loss(Groups 2～100 μg·kg -1 ·d -1 ) or reduced both body weight loss and jumping times (Group 100 μg·kg -1 ·d -1 ). In addition, concomitant treatment with ondansetron(1～20 μmol·L -1 ) dose dependently suppressed the contraction induced by naloxone in Guinea pig ileum. CONCLUSION The chronic pretreatment of ondansetron can prevent morphine physical dependence to some extent. |
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| Keywords: | ondansetron morphine physical dependence Guinea pig ileum |
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