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淫羊藿总黄酮对肾上腺素能受体阻断作用的研究
引用本文:许兰芝,陈维宁.淫羊藿总黄酮对肾上腺素能受体阻断作用的研究[J].中国药理学通报,1994,10(4):311-313.
作者姓名:许兰芝  陈维宁
作者单位:潍坊医学院药理学教研室
摘    要:淫羊藿总黄酮(TFE,0,13g·L-1)抑制兔离体右心房肌的肌力和心率,此作用无M受体激动效应和钙拮抗作用,能使异丙肾上腺素(ISO,10-7mol·L-1)对心房肌的正性频率作用的量效曲线平行右移。TFE不影响ISO(10-7mol·L-1)对豚鼠气管条的负性肌力作用和去甲肾上腺素(NE,10-6mol·L-1)对兔主动脉条的正性肌力作用。TFE(iv,100mg·kg-1)明显降低麻醉猫和大鼠血压,减弱ISO(10μg·kg-1)所致的大鼠心率加快的作用,但对ISO和肾上腺素(Adr)的降压作用无影响,也不增敏Adr的升压作用。实验结果证实TFE选择性阻断离体及整体动物心肌β1受体,对气管β2受体和血管平滑肌α受体无阻断作用。

关 键 词:淫羊藿总黄酮  肾上腺素β受体阻滞剂  异丙基肾上腺素  心房肌  气管  动脉条

Blocking effect of total flavones of epimedium on adrenergic receptor
XU Lan-Zhi,CHEN Wei-Ning.Blocking effect of total flavones of epimedium on adrenergic receptor[J].Chinese Pharmacological Bulletin,1994,10(4):311-313.
Authors:XU Lan-Zhi  CHEN Wei-Ning
Abstract:Total flavones of epimedium(TFE)(0. 13 g·L-1) inhibited the contractility and beat rate of isolated myocardium of rabbit right atrium,with no effect on M-receptor excitation and Ca2+ antagonism.But could cause parallel rightward shift of positive chronotropic dose-response curve by ISO(10-7mol·L-1) on isolated myocardium.TFE(0.13 g·L-1) did not affect the negative inotropic action of ISO (10-7mol·L-1) on isolated trachea of guinea pig.TFE iv(100 mg·kg-1)markedly decreased blood pressure of anesthetized cat and rat, and alleviated rat tachycardia by ISO(10 mg·kg-1)but no effect on ISO hypotensive action nor on sensitization of Adr hypertension action. Results indicate that TFE is a selective β1adrenoceptor blocking agent but not that of β2-and α-adrenoceptors.
Keywords:flavons of epimedium  beta-receptor-blocking agent  isoprenaline  right atrium  trachea strip  aortic strip
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