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女贞子多糖抗肿瘤作用研究
引用本文:李璘,邱蓉丽,程革,施樱樱,韩莹,高羽,陆茵.女贞子多糖抗肿瘤作用研究[J].中国药理学通报,2008,24(12).
作者姓名:李璘  邱蓉丽  程革  施樱樱  韩莹  高羽  陆茵
作者单位:南京中医药大学中医药研究院药理室,江苏,南京,210029
基金项目:江苏省高校自然科学基金资助项目 , 江苏省中医药管理局基金资助项目  
摘    要:目的探讨女贞子多糖(LLP)的抗肿瘤作用及机制。方法观察LLP对小鼠肉瘤(S180)、小鼠肝癌(H22)的抑制作用;采用MTT法观察LLP对人肝癌细胞(SMMC-7721)增殖的影响;ConA刺激T-淋巴细胞法研究LLP的免疫刺激作用。结果LLP对S180、H22实体瘤均有抑制作用(P<0.05);对SMMC-7721肿瘤细胞无直接杀伤作用,可提高Co-nA对T淋巴细胞刺激的转换率,提高由淋巴细胞YAC-1所致NK细胞的活性。结论LLP具有抗实体肿瘤的作用,LLP抗实体瘤的作用与其提高机体免疫,改善机体免疫能力而抑制肿瘤细胞生长有关。

关 键 词:女贞子  多糖  抗肿瘤

The study on the anti-tumor effect of LLP in vitro and in vivo
LI Lin,QIU Rong-li,CHENG Ge,SHI Ying-ying,HAN Ying,GAO Yu,LU Yin.The study on the anti-tumor effect of LLP in vitro and in vivo[J].Chinese Pharmacological Bulletin,2008,24(12).
Authors:LI Lin  QIU Rong-li  CHENG Ge  SHI Ying-ying  HAN Ying  GAO Yu  LU Yin
Institution:LI Lin,QIU Rong-li,CHENG Ge,SHI Ying-ying,HAN Ying,GAO Yu,LU Yin(Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China)
Abstract:Aim To investigate the anti-tumor activity of the polysaccharides from Ligustrum lucidum Ait(LLP) on the proliferation of tumor cells in vitro and in vivo. Methods The effect of LLP on the proliferation of human tumor cells SMMC-7721was evaluated by using MTT assay. Its in vivo anti-tumor activity was studied by observing its effect on the weight of tumors in S180 and H22 tumor bearing mice and the life spans of EAC tumor bearing mice. Results LLP had an obvious inhibition on formation of the above tumor ce...
Keywords:Ligustrum lucidum Ait  polysaccharides  anti-tumor activity  
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