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丁苯乙肟对甲醛皮肤致炎模型的抗炎作用研究
引用本文:孙海英,李万亥,刘丽琳.丁苯乙肟对甲醛皮肤致炎模型的抗炎作用研究[J].中国药理学通报,1988(3).
作者姓名:孙海英  李万亥  刘丽琳
作者单位:第二军医大学药学系中西药研究室 上海 (孙海英,李万亥),第二军医大学药学系中西药研究室 上海(刘丽琳)
摘    要:以甲醛致炎的小白鼠模型研究丁苯乙肟的皮肤局部抗炎作用。0.5%的丁苯乙肟霜剂的作用与霜剂基质比较无明显差异;1%的霜剂在1h、2h和2%、5%的在1h、2h、4h与基质比较均有显著差异,抗炎作用随浓度增大而增强。丁苯乙肟2%的浓度可产生与1%消炎痛和0.05%的氯培他索相近似的抗炎作用。本研究还显示非甾体及甾体抗炎剂对甲醛致炎模型均有显著的局部抗炎活性。致炎剂甲醛价廉易得,用于局部抗炎药筛选有一定价值。

关 键 词:丁苯乙肟  消炎痛  氯培他索  抗炎作用

ANTIINFLAMMATORY ACTIVITY OF BUFEXAMAC ON TOPICAL SKIN INFLAMMATION MODEL INDUCED BY FORMALDEHYDE
Sun Haiying,Li Wanhai & Liu Lilin.ANTIINFLAMMATORY ACTIVITY OF BUFEXAMAC ON TOPICAL SKIN INFLAMMATION MODEL INDUCED BY FORMALDEHYDE[J].Chinese Pharmacological Bulletin,1988(3).
Authors:Sun Haiying  Li Wanhai & Liu Lilin
Abstract:The paper reported the topical skin antiinflammatory activity of bufexamac on inflammation model induced by formaldehyde in mice. Comparing with the blank cream, the effect of 0.5% bufexamac cre-am on inflammation had no statistically difference, but all those of 1% bufexamac cream at 1 and 2 h after treatment, of 2 % and 5 % bufexamac cream at 1, 2 and 4h after treatment, showed significantly difference. The antiinflammatory activity was enhanced with the increase of bufexamac concentration in cream. The antiinflammatory activity of 2 % bufexamac cream was close to the effects of 1 % indomethacin cream and 0.05 % clobetasol Cream. Furthermore, our study showed that steroid antiinflammatory agents and nonsteroid antiinflammatory agents were all active against erythema and edema produced by formaldehyde in mice. Formaldehyde and mice are cheap and easy to obtain in our country. It is of some value to use the animal model for screening the topical skin antiinflammatory agents.
Keywords:Bufexamac  Indomethacin  Clobetasol  Antiinflammation  
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