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| 利莫那班减肥作用及机制研究进展 | |
| 引用本文： | 汤劐菱,王莉莉,王莉,李松.利莫那班减肥作用及机制研究进展[J].中国药理学通报,2007,23(7):844-847. |
| 作者姓名： | 汤劐菱 王莉莉 王莉 李松 |
| 作者单位： | 1. 四川大学华西药学院 2. 军事医学科学院毒物药物研究所,北京,100850 3. 国家成都中药安全性评价中心,四川,成都,610041 |
| 摘 要： | 大麻素受体1(CB1)广泛分布于中枢神经系统和外周组织器官,激活后具有促进食欲作用。利莫那班是高效的选择性CB1受体拮抗剂,不仅能明显减低食欲、减轻体重,而且能有效改善肥胖症伴发的高血糖、胰岛素抵抗和脂代谢紊乱。利莫那班发挥作用的机制,一是通过作用于中枢神经系统CB1受体抑制食欲、减少摄食,二是作用于外周组织的CB1受体调节体内能量代谢,从而减轻体重。 |
| 关 键 词： | CB1 利莫那班 肥胖 |
| 文章编号： | 1001-1978（2007）07-0844-04 |
| 修稿时间： | 2007-01-112007-04-20 |
Research progress on the antiobesity effects and mechanism of cannabinoid receptor type |
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| TANG Huo-ling,WANG Li-li,WANG Li,LI Song.Research progress on the antiobesity effects and mechanism of cannabinoid receptor type[J].Chinese Pharmacological Bulletin,2007,23(7):844-847. | |
| Authors: | TANG Huo-ling WANG Li-li WANG Li LI Song |
| Institution: | 1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Belling 100850, China; 2. Pharmacy school of Western China, Sichuan University; 3. National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine, Chengdu 610041, China |
| Abstract: | The CB1 receptor belongs to the G protein-coupled receptor families and are distributed extensively in the nervoussystem and peripheral tissues. Higher CB1 receptor system activity exhibits in obesity and the CB1 receptor is believed as an orexigenic receptor. It had been showed that rimonabant, a potent and selective antagonist of the CB1 receptor, has the ability to reduce body weight significantly and has been permitted to enter market for obesity therapy recently. Lots of researches have demonstrated that the initial reduction of body weight may be attributed to the severe anorexia induced by rimonabant, the following lasting effect of the drug on body weight loss might be due to an increase induced by it in energy expenditure. |
| Keywords: | CB1 |
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