头孢硫脒与环丙沙星对革兰阳性球菌的联合药敏研究

目的　评价头孢硫脒 /环丙沙星对于临床分离的金黄色葡萄球菌(包括耐甲氧西林金葡菌)、表皮葡萄球菌 (包括耐甲氧西林表葡菌)、粪肠球菌的体外联合抗菌效应。方法采用棋盘法设计,微量肉汤稀释法测定。测定不同浓度组合的抗菌药物对 90株临床分离的革兰阳性球菌的最低抑菌浓度,并计算FIC指数判定联合效应。结果　头孢硫脒 /环丙沙星联合应用后,其MIC50明显降低。FIC≤0 5占 53 3% ~93 3%; 0 52为 0。结论　环丙沙星与头孢硫脒联合用药对革兰阳性球菌主要表现为协同作用。

A study on the antibacterial activity of cefathiamidine combined with ciprofloxacin against Gram-positive cocci

Aim To study the in virto interaction o f Cefathiamidine in combination with Ciprofloxacin against clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis. Methods The activity of each drug alone was determined against all the isolates. Chequerborad synergy testing was then performed against all the isolat es. Results The percentage of the FIC index less than 0.5, from 0.5 t o 1,from 1 to 2,more than 2 was 53.3%～93.3%,6.7%～46.7%,0%,0% respectiv ely. Conclusion Synergism and additivity of cefathiamidine comb ined with ciprofloxacin respectively against 90 strains of Gram positive cocci w ere the main inter actions, there were little autonomy and no antagonism.