蛋白降解途径在帕金森病发病中的作用

帕金森病重要的病理特征是Lewy bodies的出现,α-sy-nuclein蛋白是Lewy bodies的主要成分。近年来研究表明,帕金森病等神经退行性疾病的发病机制与神经细胞内蛋白积聚有密切的联系,而蛋白的降解是细胞防御蛋白过度积聚的重要手段。泛素-蛋白酶体系统和溶酶体自吞噬途径是细胞内两种重要的蛋白降解途径,在细胞内可溶性蛋白的降解过程中扮演重要角色。该文对细胞内两种重要的蛋白降解途径和帕金森病的发生发展机制以及植物雌激素等对帕金森病的保护策略进行综述。

The relation between protein degradation pathways and parkinson's disease

Lewy bodies are one hallmark of Parkinson's disease. α-synuclein is a typical component in the Lewy bodies. Recently,the relationship between neuron degeneration diseases and the protein accumulation in neurons has already been verified,especially in Parkinson's disease. Degradation is one way to defend largely accumulating protein. Ubiquitin-proteasome system and chaprone-mediated autophagy pathway are two key protein degradation pathways,which are responsible for degradation soluble protein. This paper aims sum up the relationship between the protein degradation pathways and Parkinson's disease,and has also referred to the protective strategy of phytoestrogen to Parkinson's disease.