| 孕酮对缺氧缺血性脑损伤新生大鼠血脑屏障通透性及脑水肿的影响 |
| |
| 引用本文： | 李新娟,李爽,李东亮.孕酮对缺氧缺血性脑损伤新生大鼠血脑屏障通透性及脑水肿的影响[J].中国药理学通报,2011,27(3):364-367. |
| |
| 作者姓名： | 李新娟 李爽 李东亮 |
| |
| 作者单位： | 新乡医学院生理学与神经生物学教研室,河南,新乡,453003 |
| |
| 基金项目： | 河南省科技攻关项目资助课题 |
| |
| 摘 要： | 目的研究孕酮(PROG)对缺氧缺血性脑损伤(HIBD)新生大鼠血脑屏障(BBB)通透性和脑水肿的作用,并进一步探讨其潜在的机制。方法 7 d龄SD大鼠96只,随机分成4组:正常组、假手术组、缺氧缺血(HI)组和PROG组。建立HIBD动物模型,HI后24 h,伊文思蓝示踪剂检测BBB;干/湿法测定脑含水量;免疫组织化学法观察大脑皮质水孔通道蛋白4(AQP4)表达。结果正常组和假手术组BBB通透性、脑含水量和脑皮质AQP4的表达差异无显著性(P>0.05);HI组BBB通透性、脑含水量和脑皮质AQP4的表达明显高于假手术组(P<0.01);PROG组BBB通透性、脑含水量和脑皮质AQP4的表达明显低于HI组(P<0.05)。结论 PROG通过减轻BBB破坏和脑水肿对HIBD新生大鼠起脑保护作用,PROG的脑保护作用可能与下调新生大鼠脑皮质AQP4的表达有关。
|
| 关 键 词： | 孕酮 缺氧缺血 血脑屏障 脑水肿 水通道蛋白 大鼠 |
Effects of progesterone on blood brain barrier permeability and brain edema following hypoxic-ischemic brain damage in newborn rats |
| |
| LI Xin-juan,LI Shuang,Li Dong-liang.Effects of progesterone on blood brain barrier permeability and brain edema following hypoxic-ischemic brain damage in newborn rats[J].Chinese Pharmacological Bulletin,2011,27(3):364-367. |
| |
| Authors: | LI Xin-juan LI Shuang Li Dong-liang |
| |
| Institution: | LI Xin-juan,LI Shuang,Li Dong-liang(Dept of Physiology and Neurobiology,Xinxiang Medical University,Xinxiang Henan 453003,China) |
| |
| Abstract: | Aim To explore the effects of progesterone(PROG) on blood brain barrier(BBB) permeability and brain edema in newborn rats following hypoxic-ischemic brain damage(HIBD),and to further investigate its potential mechanisms.Methods Ninety six SD rats(7-day-old),were divided randomly into four groups that were normal group,sham operated group,hypoxic-ischemic(HI) group and PROG group.Followed the HIBD of neonatal rat.Rats were executed 24 hours after modeling.BBB permeability was detected by using Evans blue(EB)... |
| |
| Keywords: | progesterone hypoxic-ischemic blood-brain barrier brain edema aquaporin rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
