| 肿瘤细胞内pH值改变与肿瘤多药耐药的关系 |
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| 引用本文： | 芦颖,李庆华,庞天翔.肿瘤细胞内pH值改变与肿瘤多药耐药的关系[J].中国药理学通报,2007,23(9):1128-1130. |
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| 作者姓名： | 芦颖 李庆华 庞天翔 |
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| 作者单位： | 中国医学科学院中国协和医科大学血液学研究所血液病医院·实验血液学国家重点实验室,天津,300020 |
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| 基金项目： | 国家自然科学基金;天津市自然科学基金 |
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| 摘 要： | 细胞内pH值(pHi)增高是许多耐药肿瘤的共同特点,其结果引起肿瘤细胞对化疗药物的敏感性下降,降低药物疗效。通过对pHi的调节,可纠正细胞内碱化,逆转肿瘤耐药。Na+-H+交换蛋白(Na+/H+exchanger,NHE)抑制剂可通过抑制NHE的活性调节pHi,为肿瘤的治疗提供了新的思路和手段。
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| 关 键 词： | 细胞内pH值 多药耐药 P-糖蛋白 Na~+-H~+交换蛋白 |
| 文章编号： | 1001-1978（2007）09-1128-03 |
| 修稿时间： | 2007-04-302007-07-01 |
The relationship between tumor intracellular pH and tumor multiple drug resistance |
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| LU Ying,LI Qing-hua,PANG Tian-xiang.The relationship between tumor intracellular pH and tumor multiple drug resistance[J].Chinese Pharmacological Bulletin,2007,23(9):1128-1130. |
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| Authors: | LU Ying LI Qing-hua PANG Tian-xiang |
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| Institution: | State key Laboratory of Experimental Hematology;Institute of Hematology and Hospital of Blood Diseases;Chiese Academy of Medical Sciences and Peking Union College;Tianjin 300020;China |
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| Abstract: | The elevation of tumor intracellular pH(pHi) is the common character of tumor multiple drug resistance(MDR),which makes the tumor insensitive to chemotherapeutics and decreases the therapeutic effect.The reverse of tumor MDR can be achieved by regulating the pHi.The pHi can be regulated by the inhibition of Na+/H+ exchanger,which provides a new approach to tumor treatment. |
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| Keywords: | intracellular pH multiple drug resistance P-glycoprotein Na+/H+ exchanger |
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