Research progress of Gasdermin D北大核心CSCD |
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引用本文: | 李陈广,麦凤怡,梁靖蓉,肖礼祖,张治国.Research progress of Gasdermin D北大核心CSCD[J].中国药理学通报,2023(5):817-822. |
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作者姓名: | 李陈广 麦凤怡 梁靖蓉 肖礼祖 张治国 |
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作者单位: | 1. 深圳大学医学部生物医学工程学院;2. 华中科技大学协和深圳医院疼痛科;3. 南方科技大学医学院 |
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基金项目: | 中国博士后基金面上项目(No 2021M692207,2021M702276); |
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摘 要: | Pyroptosis is a novel process of programmed inflammatory necrosis, which is closely related to microbial infections and autoimmune diseases. In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis. Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis, and the release of inflammatory factors such as IL-1β and IL-18 aggravates the occurrence of inflammatory responses. With the deepening of Gasdermin D research, it is gradually clear its protein structure and activation sites, which has other activation pathways apart from inducing inflammasome activation. Activation of Gasdermin D does not necessarily mean cell death, even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion. These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis. The recent progress of Gasdermin D is highlighted in this review. © 2023 Publication Centre of Anhui Medical University. All rights reserved.
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关 键 词: | Gasdermin D Gasdermin家族 细胞焦亡 炎症小体 炎症 |
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