蛋白质组学在吗啡依赖分子机制研究中的应用

目前蛋白质组学技术被广泛应用于生物医学的各种研究领域,而在吗啡依赖分子机制的蛋白质组学研究方面才刚刚起步。该文通过介绍各种蛋白质组学技术在吗啡依赖分子机制研究中的应用及发现一些潜在的吗啡依赖分子标记物,从而肯定了蛋白质组学在研究吗啡依赖分子机制中的重要性。吗啡依赖蛋白质组学的研究策略应包括吗啡依赖动物和细胞模型的建立、选择合适的样品来源以及改进蛋白质组学技术等,为进一步阐明吗啡依赖分子机制和寻找新的治疗药物靶点提供研究思路和新方法。

Application of proteomics in the study of molecular mechanism of morphine dependence

Proteomics has been applied in a wide range of biomedical research. However,the application of proteomics in studying the molecular mechanism of morphine dependence is only at a preliminary stage. This article introduced the application of proteomics techniques in the study of the molecular mechanism of morphine dependence and the discovery of several potential molecular markers of morphine dependence, which affirmed the importance and potential of proteomics in this research area. Also, it was pointed out that the major tasks of current proteomic study of morphine dependence should include establishing animal and cell models of morphine dependence, selecting appropriate sample source and improving proteomics techniques, so that proteomics can serve as a new approach in the study of morphine dependence to discover new therapeutic targets.