亲代谢型谷氨酸受体配基对黑质6-羟基多巴损毁大鼠的抗氧化作用

目的　探讨亲代谢型谷氨酸受体 (mGluRs)配基对帕金森病 (PD )模型大鼠的抗氧化作用。方法　采用 6 羟基多巴单侧黑质损毁建立帕金森病大鼠模型 ,应用化学比色法测定血清总抗氧化能力 (T AOC)、抑制活性氧能力 (ROS)和谷胱甘肽 (GSH )含量。结果　与模型对照组相比 ,Ⅰ组mGluRs拮抗剂 (SIB 1893 ) ,Ⅱ组mGluRs激动剂 (APDC) ,Ⅲ组mGluRs激动剂 (L SOP )和L DOPA均能增加血清T AOC和GSH水平 ,提高清除ROS能力 ,尤以APDC组作用最明显。结论　Ⅰ组mGluRs拮抗剂和Ⅱ、Ⅲ组mGluRs激动剂对 6 羟基多巴损毁大鼠具有部分抗氧化功能 ,有利于机体减轻氧化应激所致的损伤

Antioxidation of metabotropic glutamate receptors ligand on unilateral substantia nigral 6-hydroxydopamine-lesioned rat

AIM To explore the antioxidation of metabotropic glutamate receptors (mGluRs)ligand on rat models of Parkinson disease. METHODS The rat models of Parkinson disease were established by employing 6 hydroxydopamine to lesion unilateral substantia nigral. The serum total antioxidative capability (T AOC), reactive oxygen species (ROS) inhibition competence and content of glotathione (GSH) were measured with chemical colorimetry. RESULTS Compared with control group, serum T AOC and GSH and ROS inhibition competence increased in all treatment groups, mGluRs antagonist (SIB 1893) group, mGluRs agonists (APDC ) group, mGluRs agonists ( L SOP) group and L DOPA group. The effect of APDC was most prominent. CONCLUSION mGluRs antagonist and mGluRs agonists may exert a partial antioxidation effect on unilateral substantia nigral 6 hydroxydopamine lesioned rat and may be beneficial to the body for alleviating the oxdative stress.