| 丹皮总苷体外对三类免疫细胞功能的影响 |
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| 引用本文： | 王斌,葛志东,周爱武,陈敏珠,徐叔云.丹皮总苷体外对三类免疫细胞功能的影响[J].中国药理学通报,1999,15(1):63-65. |
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| 作者姓名： | 王斌 葛志东 周爱武 陈敏珠 徐叔云 |
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| 作者单位： | 安徽医科大学临床药理研究所 |
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| 基金项目： | 安徽省科委“八五”攻关研究项目 |
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| 摘 要： | 目的研究丹皮总苷（ＴＧＭ）体外对３类免疫细胞功能的影响。方法采用［３Ｈ］－ＴｄＲ参入法，检测Ｔ淋巴细胞增殖反应和分泌白介素２（ＩＬ－２）活性，Ｂ淋巴细胞增殖反应以及巨噬细胞产生ＩＬ－１。结果ＴＧＭ２～５０ｍｇ·Ｌ－１可明显促进刀豆蛋白Ａ诱导小鼠Ｔ淋巴细胞增殖反应和大鼠Ｔ淋巴细胞产生ＩＬ－２，ＴＧＭ还可促进脂多糖诱导Ｂ淋巴细胞增殖反应以及大鼠腹腔巨噬细胞产生ＩＬ－１，它们的浓度－效应曲线呈钟罩形。结论ＴＧＭ具有浓度依赖性双向免疫调节作用。
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| 关 键 词： | 丹皮总苷 T淋巴细胞 B淋巴细胞 巨噬细胞 免疫功能 |
Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro |
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| WANG Bin,GE Zhi Dong,ZHOU Ai WU,CHEN Min Zhu,XU Shu Yun.Effects of total glucosides of mudan cortex on functions of three types of immune cells in vitro[J].Chinese Pharmacological Bulletin,1999,15(1):63-65. |
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| Authors: | WANG Bin GE Zhi Dong ZHOU Ai WU CHEN Min Zhu XU Shu Yun |
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| Abstract: | AIM To study the effects of total glucosides of mudan cortex (TGM) on functions of three types of immune cells in vitro . METHODS T lymphocyte proliferation and its interleukin 2 (IL 2) secretion, B lymphocyte proliferation, IL 1 production by peritoneal macrophages were measured by TdR incorporation. RESULTS TGM 2￣50 mg·L -1 could significantly promote murine T lympocyte proliferation and IL 2 secretion by rat T lymphocyte induced by concanavalin A, and murine B lymphocyte proliferation as well as IL 1 production of rat peritoneal macrophages induced by lipopolysaccharide. Their concentration effect curves showed the bell shaped. CONCLUSION TGM has a dual immunomodulatory activity in a concentration related way. |
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| Keywords: | total glucosides of mudan cortex T lymphocytes B lymphocytes macrophages immune functions |
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