莲房原花青素对大鼠实验性心肌缺血的保护作用

目的　观察莲房原花青素 (LSPC)对实验性心肌缺血的保护作用。方法　以diltiazem (10mg·kg-1·d-1)和复方丹参 (8mg·kg-1·d-1)为阳性对照 ,LSPC治疗性口服给药 1h后 ,分别采用大鼠皮下注射异丙肾上腺素 (Iso ,40mg·kg-1·d-1,共 2d)造成心肌损伤模型和大鼠冠脉结扎引起急性心肌缺血模型。结果　LSPC可剂量依赖性拮抗Iso引起的大鼠心肌酶释放量、心肌钙含量的增加 ,缩小心肌梗死面积 ,并可缓解心肌组织病理损伤程序 ,升高超氧化物歧化酶与丙二醛的比值。结论　提示LSPC对大鼠心肌缺血损伤有一定保护作用 ,其作用可能与抗脂质过氧化、抗心肌钙超载有关

Protective effects of procyanidins' extract from the lotus' seedpod on experimental myocadial injury in rat

AIM To study the effects of procyanidins' extract from the lotus' seedpod(LSPC) on experimental myocardia injury in rats. METHODS Compared with diltiazem(10 mg·kg -1 ·d -1 ) and complex salvia (8 mg·kg -1 ·d -1 ), after one hour supplementation of LSPC, the model of myocardial injury induced by subcutaneous injection of isoproterenol (40 mg·kg -1 , twice )and by cardiac ischemia in situ were studied with rat hearts. RESULTS LSPC pretreatment (100 and 200 mg·kg -1 ) significantly antagonized the high serum of CK,CK MB,LDH, calcium and the high content of myocardial water, calcium, provided significant reduction in myocardial infarct size, increased the ratio between superoxide dismutase activity and malondialdehyde production in serum, lighted the degree of myocardial pathological damage. CONCLUSION LSPC provided a protection on ischemic myocardium in rats and the action is considered to be related to the inhibition of lipid peroxidation or myocardial Ca 2+ accumulation.