| eNOS:糖尿病内皮祖细胞功能失调的一个关键因素 |
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| 引用本文： | 邓亚萍,赵婷,倪敏,谢和辉,沈甫明.eNOS:糖尿病内皮祖细胞功能失调的一个关键因素[J].中国药理学通报,2012,28(7):901-903. |
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| 作者姓名： | 邓亚萍 赵婷 倪敏 谢和辉 沈甫明 |
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| 作者单位： | 1. 第二军医大学药学院药理学教研室,上海,200433
2. 长征医院药材科,上海,200433 |
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| 基金项目： | 国家自然科学基金面上项目(No 81070118,81170115);科技部新药创制专项资助项目(No 2010ZXG0090X-005,2011ZXJ09201-012) |
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| 摘 要： | 糖尿病是由多种病因引起的,以慢性高血糖为特征的代谢紊乱综合征。糖尿病患者内皮祖细胞(EPCs)数目减少,动员、迁移、归巢、分化能力明显降低,这可能是引起糖尿病大血管并发症的主要原因之一。内皮型NO合酶(eNOS)是调节内皮祖细胞功能的关键酶。该文就eNOS与糖尿病内皮祖细胞功能失调的相关性进行综述,为糖尿病治疗提供新的思路。
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| 关 键 词： | 糖尿病 内皮祖细胞 eNOS脱耦联 一氧化氮 氧化应激 四氢生物蝶呤 |
eNOS:a key factor behind the dysfunction of endothelial progenitor cells in diabetes mellitus |
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| DENG Ya-ping
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ZHAO Ting
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NI Min
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Xie He-hui
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SHEN Fu-ming.eNOS:a key factor behind the dysfunction of endothelial progenitor cells in diabetes mellitus[J].Chinese Pharmacological Bulletin,2012,28(7):901-903. |
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| Authors: | DENG Ya-ping ZHAO Ting NI Min Xie He-hui SHEN Fu-ming |
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| Institution: | 1(1.Dept of Phamcology,the Second Military Medical University,Shanghai 200433,China; 2.Dept of Pharmacy,Changzheng Hospital,Shanghai 200433,China) |
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| Abstract: | Diabetes mellitus is a disorder characterized by a chronically raised blood glucose level and caused by multiple pathogenic factors.Recent researches suggest that the numbers of endothelial progenitor cells(EPCs) decreased in diabetic patients.Moreover,diabetic EPCs display functional impairment,such as reduced proliferation,adhesion,migration,and incorporation into tubular structures,which is one of the main reasons contributing to blood vessel damage.Endothelial nitric oxide synthase(eNOS) plays an important role in the process of EPCs mobilization and in the regulation of EPCs function.To provide new strategies for treatment of diabetes mellitus,the role of eNOS on EPCs dysfunction is reviewed in this paper. |
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| Keywords: | diabetes mellitus EPCs eNOS uncoupling NO oxidative stress tetrahydrobiopterin |
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