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白花蛇舌草总黄酮的抗炎及抗菌作用
引用本文:王宇翎,张艳,方明,李前进,江勤,明亮.白花蛇舌草总黄酮的抗炎及抗菌作用[J].中国药理学通报,2005,21(3):348-350.
作者姓名:王宇翎  张艳  方明  李前进  江勤  明亮
作者单位:安徽医科大学药理学教研室,安徽,合肥,230032
基金项目:安徽省科技厅引导型资助项目
摘    要:目的观察白花蛇舌草总黄酮抗炎及抗菌作用。方法采用二甲苯诱导小鼠耳肿胀模型、大鼠松节油气囊肉芽增生模型、新鲜蛋清诱导大鼠足爪肿胀模型、醋酸所致小鼠毛细血管通透性增高试验和体外抗菌试验,观察白花蛇舌草总黄酮的抗炎及抗菌作用。结果白花蛇舌草总黄酮(15、30、60mg·kg-1)对二甲苯诱导的小鼠耳肿胀和醋酸所致小鼠毛细血管通透性增高有一定的抑制作用;白花蛇舌草总黄酮(12、24、48mg·kg-1)对大鼠松节油气囊肉芽增生和新鲜蛋清诱导大鼠足爪肿胀亦有明显的抑制作用;在体外,白花蛇舌草总黄酮对球菌和杆菌均具有不同程度的抑菌和杀菌作用,且对球菌的作用优于杆菌。结论白花蛇舌草总黄酮具有抗炎及抗菌作用。

关 键 词:白花蛇舌草总黄酮  抗炎  抗菌
文章编号:1001-1978(2005)03-0348-03
修稿时间:2004年8月5日

Anti-inflammatory and antibacterial effects of total flavones of oldenlandia diffusa willd
WANG Yu-ling,ZHANG Yan,FANG Ming,LI Qian-jin,JIANG Qing,MING Liang.Anti-inflammatory and antibacterial effects of total flavones of oldenlandia diffusa willd[J].Chinese Pharmacological Bulletin,2005,21(3):348-350.
Authors:WANG Yu-ling  ZHANG Yan  FANG Ming  LI Qian-jin  JIANG Qing  MING Liang
Abstract:Aim To study anti-inflammatory and antibacterial effects of total flavones of oldenlandia diffusa Willd(FOD).Methods The models of dimethylbenzene-induced ear swollen in mice,turpentine-induced granuloma pouch in rats,paw edema caused by egg white in rats,increased vascular permeability by acetic acid in mice and the antibacterial activity in vitro were used to study FOD. Results FOD(15、30 and 60 mg·kg~-1 )show a marked suppressive effect on dimethylbenzene-induced ear swollen and increased vascular permeability in mice. In addition,FOD(12、24 and 48 mg·kg~-1 ) could reduce the paws edema and the granuloma pouch in rats.On the other hand,FOD had significally bacteriostatic effects against eight kinds of bacterial in vitro, in which effect on coccus is superior to that on bacillus.Conclusion FOD has anti-inflammatory and antibacterial effects.
Keywords:total flavones of oldenlandia diffusa willd(FOD)  anti-inflammatory  antibacterial
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