| TSPO:外周苯二氮卓受体的新命名及其在中枢神经系统中的作用 |
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| 引用本文： | 赵悦,左萍萍,郎森阳.TSPO:外周苯二氮卓受体的新命名及其在中枢神经系统中的作用[J].中国药理学通报,2010,26(4). |
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| 作者姓名： | 赵悦 左萍萍 郎森阳 |
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| 作者单位： | 1. 中国医学科学院基础医学研究所、北京协和医学院基础学院药理系,北京,100005
2. 解放军301医院神经内科,北京,100853 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目 |
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| 摘 要： | 早期外周苯二氮卓受体(PBR)是根据其在外周组织的广泛分布而命名的,用以区分中枢苯二氮卓受体(CBR)。但是近年来,随着研究的不断深入,人们发现PBR已不能反映该蛋白的分布、生理特性及其功能等,故2006年Papadopoulos等提出了18ku转位蛋白translocator protein(18ku),简称TSPO,将其作为PBR的新名称。该文将从TSPO的分子特性、定位分布、生理特性,特别是其在中枢神经系统疾病进程中所扮演的角色等方面对其研究进展做一综述。
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| 关 键 词： | 外周苯二氮卓受体(PBR) 18ku转位蛋白 TSPO 中枢神经系统 神经退行性疾病 精神类疾病 |
TSPO:new nomenclature for the peripheral benzodiazepine receptor and its role in the neuropsycopharmacology |
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| ZHAO Yue,ZUO Ping-ping,LANG Sen-yang.TSPO:new nomenclature for the peripheral benzodiazepine receptor and its role in the neuropsycopharmacology[J].Chinese Pharmacological Bulletin,2010,26(4). |
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| Authors: | ZHAO Yue ZUO Ping-ping LANG Sen-yang |
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| Institution: | ZHAO Yue1,ZUO Ping-ping1,LANG Sen-yang2(1.School of Basic Medicine,Peking Union Medical College & Institute of Basic Medical Science,Chinese Academyof Medical Sciences,Beijing 100005,China,2.Dept of Neurology,Chinese PLA General Hospital,Beijing 100853,China) |
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| Abstract: | The early characterization of the diazepam-binding sites outside the brain led to their assignment as peripheralbenzodiazepine receptors, or PBRs, to distinguish them from the central benzodiazepine receptor.Although PBR is a widely used and accepted name in the scientific community,recent data regarding the structure and molecular function of this protein increasingly support renaming it to represent more accurately its subcellular role (or roles) and putative tissue-specific function (or functions). Trans... |
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| Keywords: | TSPO PBR Translocator protein (18 ku TSPO) neuropsycopharmacology neurodegenerative disease mental disorder |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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