| 内源性大麻素—生物合成、信号转导及生物降解 |
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| 引用本文： | 唐双奇,陆阳. 内源性大麻素—生物合成、信号转导及生物降解[J]. 中国药理学通报, 2013, 29(8) |
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| 作者姓名： | 唐双奇 陆阳 |
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| 作者单位： | 上海交通大学医学院,上海,200025 |
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| 基金项目： | 国家自然科学基金资助项目，上海市科委基础重点项目 |
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| 摘 要： | 大麻素系统由内源性大麻素、大麻素受体和内源性大麻素失活系统三部分组成,该系统失衡与多种中枢神经系统和免疫系统疾病有关。内源性大麻素水平是衡量大麻素系统活性的主要指标。内源性大麻素代谢途径的深入研究对揭示大麻素系统生理、病理作用以及设计基于该系统的新型治疗药物至关重要。该文综述内源性大麻素的生物合成、信号转导及其降解过程。
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| 关 键 词： | 大麻素系统 N-花生四烯酰乙醇胺 2-花生四烯酰甘油酯 生物合成途径 信号转导 降解途径 |
Endocannabinoids-biosynthesis, signal transduction and biodegradation |
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| TANG Shuang-qi , LU Yang. Endocannabinoids-biosynthesis, signal transduction and biodegradation[J]. Chinese Pharmacological Bulletin, 2013, 29(8) |
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| Authors: | TANG Shuang-qi LU Yang |
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| Abstract: | Endocannabinoids,endocannabinoid receptors and endocannabinoids hydrolyzing enzymes are three main elements of the endocannabinoid system.The imbalance of this system causes numerous diseases of center nervous system and immune system.The levels of endocannabinoids are the major parameters of the endocannabinoid system activity.An in-depth research of the metabolic pathways of the endocannabinoids is essential to unravel the endocannabinoid system's role in physiological and pathological situations and to devise new therapeutic drugs based on the endocannabinoid system.The present article reviews the advanced progress in the biosynthesis,signal transduction and degradation of the endocannabinoids |
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| Keywords: | endocannabinoid system anandamide 2-arachidonoylglycerol biosynthetic pathways signal transduction degradation pathways |
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