蛇毒解离素的结构特征及其与生物学活性的关系

目前已从蛇毒中分离出 80余种解离素多肽,根据其结构及来源可分为五大类,即短链、中链、长链解离素、金属蛋白酶P Ⅲ的类解离素区释放的解离素以及二聚体解离素。不同解离素的分子结构共同点包括RGD活性中心、半胱氨酸残基配对形成的二硫键、RGD三肽的C 端和N 端的氨基酸序列以及解离素多肽分子的C 末端。这些结构决定了解离素的抑制血小板聚集、抑制细胞粘附以及血管形成等生物学活性。

Structural and functional characterization of snake venom disintegrins

According to their polypeptide length and number of d is ulphide bonds, disintegrins are divided into five groups, including short-sized disintegrins, medium-sized disintegrins, long-sized disintegrins, dimeric dis integrins and disintegrin-like molecules released from the disintegrin-like do mains of P-III snake venom metalloproteinases. The integrin-inhibitory activit y of disintegrins, to inhibit platelet aggregating, cell attaching and angiogene sis, depends on the active tripeptide RGD, the appropriate pairing of cysteine r esidues, the amino acids adjacent to the RGD motif within the integrin-binding loop and the C-terminus of the disintegrin polypeptidesl as well.