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阿魏酸钠对高脂血症家兔动脉粥样硬化形成的影响及其机制的研究
引用本文:欧阳静萍,王保华,刘永明,杨静薇,魏蕾,李柯.阿魏酸钠对高脂血症家兔动脉粥样硬化形成的影响及其机制的研究[J].中国药理学通报,2002,18(2):207-210.
作者姓名:欧阳静萍  王保华  刘永明  杨静薇  魏蕾  李柯
作者单位:武汉大学医学院病理生理学教研室,武汉,430071
摘    要:目的 观察阿魏酸钠 (sodiumferulate,SF)对高脂血症导致动脉粥样硬化 (atherosclerosis,AS)的治疗作用及其机制。方法 高胆固醇喂养复制AS动物模型 ;以高脂血清(hyperlipidemicserum ,HLS)损伤培养人脐静脉内皮细胞。检测AS斑块面积 ,扫描电镜观察内皮细胞形态的改变 ,免疫细胞化学方法观测内皮细胞表面转化生长因子 β1(trans forminggrowthfactorβ1,TGFβ1)及碱性成纤维细胞生长因子(basicfibroblastgrowthfactor ,bFGF)的表达 ,并对细胞培养液中一氧化氮 (Nitricoxide,NO)的分泌量进行检测。结果 SF可明显减少斑块面积 ,改善HLS导致的内皮细胞损伤 ,使细胞表面TGFβ1的表达增高 ,bFGF的表达降低 ,细胞培养液中NO的分泌量升高。结论 SF可以降低高胆固醇导致的AS斑块面积 ,其机制与改变细胞因子的表达有关

关 键 词:阿魏酸钠  NO  TGFβ1  bFGF  动脉粥样硬化
文章编号:1001-1978(2002)02-0207-04

Experimental study of the anti-atherogenesis effects of sodium ferulate in hyperlipidemia rabbit and its mechanisms
OU YANG Jing Ping,WANG Bao Hua,LIU Yong Ming,YANG Jing Wei,WEI Lei,LI Ke.Experimental study of the anti-atherogenesis effects of sodium ferulate in hyperlipidemia rabbit and its mechanisms[J].Chinese Pharmacological Bulletin,2002,18(2):207-210.
Authors:OU YANG Jing Ping  WANG Bao Hua  LIU Yong Ming  YANG Jing Wei  WEI Lei  LI Ke
Abstract:AIM To study the anti atherogenesis action of sodium ferulate and its mechanisms. METHODS Atherosclerotic rabbit models were duplicated by feeding high lipid forage and ECV304 were cultured with the hyperlipidemic serum. The atherosclerotic plaque area was measured. Scanning electron microscope, spectrophotometer and immunocytochemical methods were used to detected the microstructures of endothelial cell, the content of NO in suspension and the expressions of TGFβ 1, bFGF on the cell surfaces. RESULTS Sodium ferulate could decrease the plaque area, lessen the damnification of endothelial cell induced by HLS, enhance the expression of TGFβ 1 and the release of NO from ECs, and reduce the expressions of bFGF in ECs, significantly. CONCLUSION Sodium ferulate can decrease the atherosclerotic plaque area induced by hypercholesterol, which may be relate to the expression change of cytokines.
Keywords:NO  bFGF
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