| N—甲基小檗胺扩血管作用原理的研究 |
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| 引用本文： | 罗大力,高云瑞.N—甲基小檗胺扩血管作用原理的研究[J].中国药理学通报,1990,6(1):30-33. |
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| 作者姓名： | 罗大力 高云瑞 |
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| 作者单位： | 哈尔滨医科大学药理学教研室，哈尔滨医科大学药理学教研室，哈尔滨医科大学药理学教研室 哈尔滨 150086，哈尔滨 150086，哈尔滨 150086 |
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| 摘 要： | N—甲基小檗胺可非竞争性抑制氯化钾、氯化钙、去甲肾上腺素引起的家兔胸主动脉条收缩。其拮抗参数pD_(2’)分别为3.44、3.67和3.73。对去甲肾上腺素引起的外钙性收缩有抑制作用,对内钙性收缩无影响,说明其作用原理与拮抗钙离子内流有关。
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| 关 键 词： | N-甲基小檗胺 家兔主动脉条 拮抗参数PD′_2 |
THE MECHANISM OF DILATING VASCULAR SMOOTH MUSCLE BY N-METHYLBERBAMINE |
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| Luo Dali,Gao Yunrui Li Wenhan.THE MECHANISM OF DILATING VASCULAR SMOOTH MUSCLE BY N-METHYLBERBAMINE[J].Chinese Pharmacological Bulletin,1990,6(1):30-33. |
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| Authors: | Luo Dali Gao Yunrui Li Wenhan |
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| Abstract: | The study showed that NMBA could inhibit the rabbit thoracic aorta contractions induced by KC1, CaCl2 and NA, and the pD' 2 values were 3.44, 3.67 and 3.73 respectively. NMBA could also antagonize the extracellular Ca2 + contraction of NA with no effect on the intra-cellular Ca2+ contraction. Comparing with verapamil, the mechanism of NMBA action was inferred to blocking Ca2+ influx during excitation. However, further study will be needed. |
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| Keywords: | N-methylberbamine Rabbit thoracic aorta antagonist parameter ( pD'~2 ) |
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