Novel antifungal diketopiperazine from marine fungus |
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| Authors: | Byun Hee-Guk Zhang Huiping Mochizuki Masami Adachi Kyoko Shizuri Yoshikazu Lee Won-Jae Kim Se-Kwon |
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| Institution: | Marine Biotechnology Institute Co. Ltd., Shimizu, Shizuoka 424-0037, Japan bhg@netian.com |
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| Abstract: | Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM. |
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