三七总皂苷治疗急性脑梗死及对血清血管内皮生长因子的影响

目的 :观察三七总皂苷对急性脑梗死(ACI)的疗效及治疗前后血清血管内皮生长因子(VEGF)水平的变化。方法 :4 0例ACI病人 ,随机分为 2组。三七总皂苷组 2 0例 ,以曲克芦丁、胞磷胆碱和三七总皂苷 (5 0 0mg ,iv ,gtt ,qd)治疗 2wk ;对照组 2 0例 ,仅用曲克芦丁、胞磷胆碱治疗。采用双抗体ELISA法分别检测治疗前后病人血清VEGF水平的变化。结果 :三七总皂苷组总有效率95 % ,对照组 6 5 %。 2组疗效比较经Ridit分析 ,P <0 .0 1。 2组病人治疗后VEGF浓度均较治疗前显著升高 (P <0 .0 1) ;三七总皂苷组较对照组升高明显 (P <0 .0 5 )。结论 :三七总皂苷可使ACI病人的VEGF浓度升高 ,有利于ACI病人的治疗恢复

Influence of Panax notoginseng saporins on serum vascular endothelial growth factor in patients with acute cerebral infarction

AIM: To observe the effect of Panax notoginseng saporins on serum vascular endothelial growth factor(VEGF) in patients with acute cerebral infarction(ACI). METHODS: Forty patients with ACI were randomly divided into two groups. Panax notoginseng saporins group( n =20) was treated with troxerutin, citicoline and Panax notoginseng saporins (500 mg, iv, gtt, qd) for 2 wk. Control group( n =20) was treated with troxerutin and citicoline only. The changes of serum VEGF level were measured using ELISA methods before and after the treatment. RESULTS: The total effective rate was 95 % for Panax notoginseng saporins group, and 65 % for control group, respectively. There was a significant difference between the two groups( P <0.01). The serum level of VEF of the two groups increased significantly after treatment( P <0.01), but the increasing rate of the Panax notoginseng saporins group was more remarkable, compared with control group( P <0.05). CONCLUSION: Panax notoginseng saporins can increase the serum level of VEGF of the patients with ACI and is beneficial to the treatment of them.