| 喉咽清含片抗病毒作用的实验研究 |
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| 引用本文： | 陈昌华,胡随瑜,王勇华.喉咽清含片抗病毒作用的实验研究[J].中国新药与临床杂志,2003,22(12):729-731. |
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| 作者姓名： | 陈昌华 胡随瑜 王勇华 |
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| 作者单位： | 中南大学湘雅医院,中西医结合研究所,湖南,长沙,410008 |
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| 摘 要： | 目的 :观察喉咽清含片的抗病毒作用。方法 :采用体外抗病毒实验 ,观察喉咽清含片对病毒致细胞病变的作用 ;采用体内抗病毒实验 ,观察喉咽清含片对病毒感染小鼠的肺指数和肺指数抑制率的影响。结果 :喉咽清含片对流感病毒甲 3型 (A3)、副流感病毒 1型 (HVJ)、腺病毒 (AdV3,AdV7)及疱疹病毒 (HSV 1,HSV 2 )所致细胞病变效应有抑制作用 ;喉咽清含片 6 .6 g·kg- 1·d- 1和 13.2 g·kg- 1·d- 1剂量 (生药量 )能降低流感病毒鼠肺适应株FM1感染小鼠的肺指数 ,肺指数抑制率分别为 2 1%和32 %。结论 :喉咽清含片有较强的抗病毒作用
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| 关 键 词： | 抗病毒药 小鼠 投药 口服 喉咽清含片 |
| 文章编号： | 1007-7669(2003)12-0729-03 |
Antivirotic effect of Houyanqing buccal tablet: an experiment study |
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| CHEN Chang hua,HU Sui yu,WANG Yong hua.Antivirotic effect of Houyanqing buccal tablet: an experiment study[J].Chinese Journal of New Drugs and Clinical Remedies,2003,22(12):729-731. |
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| Authors: | CHEN Chang hua HU Sui yu WANG Yong hua |
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| Abstract: | AIM: To investigate the antivirotic effect of Houyanqing buccal tablet. METHODS: With in vitro antivirotic experiment, the effects of Houyanqing buccal tablet on cytopathic effects (CPE) were observed. The lung indexes and the inhibitive percentage of the lung indexes in virus affected mice treated with Houyanqing buccal tablet were observed with in vivo antivirotic experiment. RESULTS: Houyanqing buccal tablet could inhibite CPE caused by influenza virus(A 3), parainfluenza virus(HVJ),adenovirus(AdV 3, AdV 7) and herpes simplex virus(HSV 1,HSV 2). Treatment with Houyanqing buccal tablet doses (crude drug) of 6.6 g·kg -1 ·d -1 and 13.2 g·kg -1 ·d -1 could decrease the lung indexes of mice caused by strain FM 1 of influenza virus( P < 0.01).The inhibitive percentages of mice lung indexes were 21 % and 32 %, respectively. CONCLUTION: Houyanqing buccal tablet has better antivirotic effect. |
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| Keywords: | antiviral agents mice administration oral Houyanqing buccal tablet |
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