| 伏立康唑的药动学/药效学及其药物监测 |
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| 引用本文： | 朱慧芳,董亚琳,尤海生,陈思颖,孙金钥.伏立康唑的药动学/药效学及其药物监测[J].中国新药与临床杂志,2012(7):367-372. |
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| 作者姓名： | 朱慧芳 董亚琳 尤海生 陈思颖 孙金钥 |
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| 作者单位： | 西安交通大学医学院第一附属医院药学部 |
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| 摘 要： | 伏立康唑为新一代三唑类抗真菌药,抗菌谱广,抗菌作用强,主要用于治疗患有进展性、可能威胁生命的真菌感染的患者。其药动学呈非线性,个体差异大。本文对伏立康唑药动学影响因素,药动学/药效学特性,血药浓度与治疗效果、不良反应间关系以及不同类患者伏立康唑药物监测作一综述,以指导临床制定个性化给药方案,提高药物治疗效果。
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| 关 键 词： | 伏立康唑 药动学 药效学 药物监测 |
Pharmacokinetics/pharmacodynamics of voriconazole and its drug monitoring |
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| ZHU Hui-fang,DONG Ya-lin,YOU Hai-sheng,CHEN Si-ying,SUN Jin-yue.Pharmacokinetics/pharmacodynamics of voriconazole and its drug monitoring[J].Chinese Journal of New Drugs and Clinical Remedies,2012(7):367-372. |
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| Authors: | ZHU Hui-fang DONG Ya-lin YOU Hai-sheng CHEN Si-ying SUN Jin-yue |
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| Institution: | (Department of Pharmacy,the First Affiliated Hospital of Medical College,Xi-an Jiaotong University,Xi-an SHAANXI 710061,China) |
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| Abstract: | Voriconazole is a new triazole antifungal drug with hroad antifungal spectrum,mainly developed for the treatment of progressivity or life-threatening fungal infection in special patients.Voriconazole has a nonlinear pharmacokinetic profile with a wide inter- and intra-individual variation.This article summarized the factors influencing the voriconazole pharmacokinetic profile,the pharmacokinetics/pharmacodynamics characteristics of voriconazole,the relationships of serum concentration,therapeutic efficacy and adverse reactions,and the therapeutic drug monitoring in different patients,in order to formulate personalization dosing regimen in clinical to improve the drug therapy effect. |
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| Keywords: | voriconazole pharmacokinetics pharmacodynamics drug monitoring |
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