| 益生菌制剂在溃疡性结肠炎治疗中的作用 |
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| 引用本文： | 梁生林,唐志鹏.益生菌制剂在溃疡性结肠炎治疗中的作用[J].中国新药与临床杂志,2006,25(6):449-452. |
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| 作者姓名： | 梁生林 唐志鹏 |
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| 作者单位： | 1. 井冈山学院医学院,药理教研室,江西,吉安,343000
2. 上海中医药大学附属龙华医院,消化内科,上海,200032 |
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| 摘 要： | 肠道菌群在溃疡性结肠炎(UC)的发病机制中起重要作用。益生菌可能通过生物拮抗、加强肠道上皮屏障功能及调节肠道免疫系统功能等机制参与防治UC,对照临床研究已经证实了益生菌对于UC的维持治疗是有益处的。需要进一步仔细评价严格设计的大样本、多中心、双盲、安慰剂对照的临床试验,研究益生菌制剂的配方、剂量、疗程、疗效和安全性等问题。
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| 关 键 词： | 结肠炎，溃疡性 腹痛 腹泻 肠道菌群 益生菌制剂 |
| 文章编号： | 1007-7669（2006）06-0449-04 |
| 收稿时间： | 2005-08-24 |
| 修稿时间： | 2005-08-242006-04-03 |
Effect of probiotics preparation in treatment of ulcerative colitis |
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| LIANG Sheng-lin,TANG Zhi-peng.Effect of probiotics preparation in treatment of ulcerative colitis[J].Chinese Journal of New Drugs and Clinical Remedies,2006,25(6):449-452. |
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| Authors: | LIANG Sheng-lin TANG Zhi-peng |
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| Institution: | 1.Pharmaceutical Teaching Room, Medical School Jingganshan College Jiangxi, Ji-an JIANGXI 343000, China; 2.Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, SHA NGHA 1 200032, China |
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| Abstract: | It has been demonstrated that the intestinal flora plays an important role in the pathogenesis of ulcerative colitis(UC).Probiotics can probably prevent and treat UC effectively through the mechanism by mainly modulating mucosal immune activity and epithelial barrier function as a biological antagonist,which has already been proven by clinical trials for maintaining UC treatment.Large samples,multi-center,double-blind, randomized,controlled clinical trials are still further needed to study the formula,dosage,duration,effects and safety of the treatment. |
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| Keywords: | colitis ulcerative abdominal pain diarrhea intestinal flora probioties preparation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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