| 微RNA对肿瘤调控机制的研究进展 |
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| 引用本文： | 耿帅,郭宏举,史宁,汤晴,常李荣. 微RNA对肿瘤调控机制的研究进展[J]. 中国新药与临床杂志, 2020, 0(4): 193-197 |
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| 作者姓名： | 耿帅 郭宏举 史宁 汤晴 常李荣 |
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| 作者单位： | 战略支援部队特色医学中心药学部 |
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| 基金项目： | 战略支援部队特色医学中心医药卫生军事医学研究课题(19ZX17)。 |
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| 摘 要： | 微RNA(miRNA)是一类长度为21~25个核苷酸的非编码小分子RNA。其通过靶向降解信使RNA(mRNA)或抑制mRNA被翻译为蛋白质参与个体发育及细胞增殖、分化、凋亡等一系列重要生物学进程,与人类多种疾病的发生、发展密切相关。miRNA作为潜在的促癌基因或抑癌基因在结直肠癌、胃癌、乳腺癌、肝癌、肺癌等的发生、发展中有调控作用,可作为某些癌症的潜在治疗靶点。
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| 关 键 词： | 微RNAS RNA,信使 肿瘤 |
Research progress of tumor regulation mechanism by microRNA |
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| GENG Shuai,GUO Hong-ju,SHI Ning,TANG Qing,CHANG Li-rong. Research progress of tumor regulation mechanism by microRNA[J]. Chinese Journal of New Drugs and Clinical Remedies, 2020, 0(4): 193-197 |
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| Authors: | GENG Shuai GUO Hong-ju SHI Ning TANG Qing CHANG Li-rong |
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| Affiliation: | (Department of Pharmacy,Strategic Support Forces Medical Center,BEIJING 100101,China) |
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| Abstract: | MicroRNA(miRNA) is a type of non-coding small molecule RNA with a length of 21-25 nucleotides. Through targeting degradation of messenger RNA(mRNA) or inhibition of mRNA translation into proteins, miRNA is involved in a series of important biological processes such as individual development, cell proliferation, differentiation and apoptosis, which are closely related to the occurrence and development of various human diseases. As a potential oncogene or tumor suppressor gene, miRNA plays a regulatory role in the occurrence and development of colorectal cancer, gastric cancer, breast cancer, liver cancer, lung cancer, etc. And miRNA can be used as a potential therapeutic target for some tumor. |
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| Keywords: | microRNAs RNA,messenger neoplasms |
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