左氧氟沙星三联疗法根除幽门螺杆菌感染106例

目的 :观察左氧氟沙星短程三联疗法根除幽门螺杆菌 (Hp)感染的疗效。方法 :1 0 6例Hp阳性病人 A组。男性 66例 ,女性 40例 ;年龄 5 9a±s1 1a;慢性浅表性胃炎 (CSG) 5 8例 ,消化性溃疡(PU) 48例]予胶态次枸椽酸铋 2 2 0mg,左氧氟沙星2 0 0mg及呋喃唑酮 2 0 0mg ,po,bid。另 1 1 0例Hp阳性病人 (B组。男性 69例 ,女性 41例 ;年龄5 7a± 9a;CSG 63例 ,PU 47例 )予奥美拉唑 2 0mg ,克拉霉素 5 0 0mg及阿莫西林 1 0 0 0mg,po,bid。疗程均为 1wk。疗程结束后 4wk及 1 2mo复查胃镜及Hp。结果 :A ,B 2组停药 1 2mo后Hp根除率各为 82 .1 % ,83 .6% ,P >0 .0 5。均无严重不良反应。每例清除Hp药费各为 1 2 3 .5元 ,5 5 5 .8元。结论 :2组Hp根除率相近 ,但A组费用较低

Levofloxacin triple therapy in eradication of Helicobacter pylori infection in one hundred and six patients

AIM: To observe the efficacy of levofloxacin triple therapy in eradication of Helicobacter pylori (Hp ) infection METHODS: One hundred and six patients with Hp infection Group A, M 66, F 40; age 59 a± s 11 a; chronic superficial gastritis (CSG) 58, peptic ulcer (PU) 48] were treated with colloidal bismuth subcitrate (CBS) 220 mg, levofloxacin 200 mg and furazolidone 200 mg, po, bid for 1 wk. The another one hundred and ten patients (Group B, M 69, F 41; age 57 a±9 a; CSG 63, PU 47) were treated with omeprazole 20 mg, clarithromycin 500 mg and amoxicillin 1 000 mg, po, bid for 1 wk. Four weeks and twelve months after anti Hp therapy endoscopy and tests for Hp were repeated. RESULTS: The eradication rates of Hp in group A and group B were 82.1 % and 83.6 % respectively ( P> 0.05). The cost of anti Hp therapy of every patient was 123.5 Yuans (RMB) in group A and 555.8 Yuans (RMB) in group B. CONCLUSION: The eradication rates of Hp in both groups are similar, without severe adverse reaction. But group A has a lower cost than group B.