盐酸劳卡胺不良反应及血药浓度

双盲法口服盐酸劳卡胺20例(12例心律失常患者,100mg,bid×1wk;8例健康志愿者以100mg或200mg交叉单剂量口服),观察服药后不良反应发生情况,并以HPLC法测定其中18例血药浓度。服药初期,失眠常见,随时间推移渐减轻以至消除;血药浓>0.4μg/mL,常见头晕、头痛。未见严重不良反应。加强血药浓度监测,及个体化给药,可减少不良反应。

Adverse reactions and serum concentration of lorcainide hydrochloride

Observation of the adverse reaction of lorcainide hydrochloride in 20 persons (12 patients with arrhythmia, 100 mg, bid po for 1 wk; 8 Volunteers crossed 100 mg or 200 mg on single dose po) by randomized double-blind and crossover test with placebo as control. The serum concentration of this drug was detected in 18 persons by HPLC method. Insomnia was common at initial period of administration and was gradually lightened or disappeared after continual administration. Dizziness and headache frequently occurred when serum drug concentration was above 0.4g/ mL. No serious adverse reaction happened. In order to strengthen therapeutic effect and reduce adverse reaction of this drug, blood concentration monitoring and individualize therapy should be performed.