国产克拉霉素的短程三联疗法根除幽门螺杆菌感染的疗效

目的 :观察国产克拉霉素的短程三联疗法根除幽门螺杆菌 (Hp)感染的疗效及不良反应。方法 :91例Hp阳性的消化性溃疡或糜烂性胃窦炎病人 ,分为A组 ( 4 7例 ,男性 4 0例 ,女性 7例 ,年龄 57a±s14a)和B组 ( 4 4例 ,男性 4 0例 ,女性 4例 ,年龄59a± 15a)。A组以奥美拉唑 2 0mg、替硝唑 50 0mg及国产克拉霉素 2 50mg ,po ,bid ;B组治疗同A组 ,只是将国产克拉霉素改为进口克拉霉素 ,疗程均为 7d。疗程结束 1mo后复查胃镜及Hp。结果 :A ,B 2组Hp根除率分别为 85%和 91% ,不良反应发生率分别为 11%和 14% ,但均能耐受 ,2组比较差异无显著意义 ,P >0 .0 5。每例抗Hp费用A组为 4 70元、B组 550元。结论 :A ,B 2组疗效相近 ,均无严重不良反应 ,但A组费用较低 ,提示国产克拉霉素可替代进口克拉霉素用于Hp根除

Efficacy of domestic clarithromycin combined short-term triple therapy for eradication of Helicobacter pylori

AIM: To determine efficacy and adverse reactions of domestic clarithromycin combined shortterm triple therapy for eradication of Helicobacter pylori (Hp). METHODS: Ninetyone patients with Hp associated peptic ulcer or chronic erosive antral gastritis were divided into 2 groups. Group A (n=47, M 40, F 7, age 57 a±s 14 a)were treated with omeprazole 20 mg, plus tinidazole 500 mg, and domestic clarithromycin 250 mg, po, bid for 1 wk; Group B (n=44, M40, F4, age 59 a±19 a) were treated with omeprazole 20 mg plus tinidazole 500 mg and imported clarithromycin 250 mg, po, bid for 1 wk. One month after antiHp therapy endoscopy and tests of Hp were repeated. RESULTS: The eradication rates of Group A and Group B were 85 % and 91 %, respectively. Adverse reactions occurred in 5 patients of Group A (11 %) and in 6 patients of Group B (14 %), but well tolerated. The results between Group A and Group B showed no significant difference (P>0.05). Cost of antiHp was 470 yuan (RMB) in Group A and 550 yuan (RMB) in Group B. CONCLUSION: The eradication rates in Hp of domestic or imported clarithromycin combined shortterm triple therapies are similar, without severe adverse reactions; but Group A has a lower cost than Group B.