| 5-单硝酸异山梨醇酯联合普萘洛尔治疗肝硬化门静脉高压 |
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| 引用本文： | 姚德胜,张广胜,杨利敏.5-单硝酸异山梨醇酯联合普萘洛尔治疗肝硬化门静脉高压[J].实用医药杂志(山东),2004,21(1):27-28. |
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| 作者姓名： | 姚德胜 张广胜 杨利敏 |
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| 作者单位： | 371医院感染科 河南新乡453000
(姚德胜，张广胜)，371医院感染科 河南新乡453000(杨利敏) |
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| 摘 要： | 目的观察5-单硝酸异山梨醇酯联合普萘洛尔对肝硬化门静脉血流动力学的影响。方法22例肝硬化患者口服5-单硝酸异山梨醇酯20mg,2次/d,普萘洛尔10～20mg,3次/d,共8周。于治疗前及治疗后4周、8周分别检测门静脉血流动力学参数。结果联合治疗后4周、8周均可以显著降低肝硬化患者门静脉内径、血流速度及血流量(P<0.01)。于治疗8周后,脾静脉内径也较治疗前缩小(P<0.05)。结论5-单硝酸异山梨醇酯联合普萘洛尔可以显著降低门静脉血流量。
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| 关 键 词： | 普萘洛尔 5-单硝酸异山梨醇酯 肝硬化 门脉高压 |
| 修稿时间： | 2003年9月26日 |
Therapeutic effect of isosorbide-5-mononitrate plus propranolol on portal hypertension in patients with hepatic cirrhosis |
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| YAO Desheng,ZHANG Guangsheng,YANG Limin.Therapeutic effect of isosorbide-5-mononitrate plus propranolol on portal hypertension in patients with hepatic cirrhosis[J].Practical Journal of Medicine & Pharmacy,2004,21(1):27-28. |
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| Authors: | YAO Desheng ZHANG Guangsheng YANG Limin |
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| Institution: | YAO Desheng,ZHANG Guangsheng,YANG Limin.Department of Infectious Disease,the371st Hospital of PLA,Xinxiang45300,China |
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| Abstract: | Objective To observe the therapeutic effect of isosorbide-5-mononitrate plus propranolol on portal hypertension in patients with hepatic cirrhosis.Methods The22cases of hepatic cirrhosis received isosorbide-5-mononitrate plus propranolol orally for8weeks.Portal blood flow and splenic blood flow were assessed at baseline,4weeks and8weeks after treatment.Results Compared with these indexes of pre-treatment,4weeks and8weeks after treatment,the indexes of portal blood flow were significantly decreased(P<0.01),8weeks after treatment,the inner diameter of splenic vein was obviously decreased (P<0.05).Conclusio n Isosorbide -5-mononitrate plus propranolol can cause a significant decrease in portal blood flow. |
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| Keywords: | Propranolol Isosorbide-5-mononitrate Hepatic cirrhosis Portal hypertension |
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